REGISTRATION NO. 333-84566
AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON DECEMBER 20, 2002


                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                               AMENDMENT NO. 3 TO

                                  FORM S-3
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933
                               EPIX MEDICAL, INC.
              (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

           DELAWARE                                             04-3030815
           --------                                             ----------
(State or other jurisdiction of                              (I.R.S. Employer
incorporation or organization)                              Identification No.)

                                71 ROGERS STREET
                         CAMBRIDGE, MASSACHUSETTS 02142
                            TELEPHONE: (617) 250-6000

   (ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER, INCLUDING AREA CODE, OF
                    REGISTRANT'S PRINCIPAL EXECUTIVE OFFICES)

                                 MICHAEL D. WEBB
                             CHIEF EXECUTIVE OFFICER
                                71 ROGERS STREET
                         CAMBRIDGE, MASSACHUSETTS 02142
                                 (617) 250-6000
     (NAME, ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE, INCLUDING AREA CODE,
                             OF AGENT FOR SERVICE)

                                    COPY TO:

                             WILLIAM T. WHELAN, ESQ.
                           MINTZ, LEVIN, COHN, FERRIS,
                             GLOVSKY AND POPEO, P.C.
                              ONE FINANCIAL CENTER
                           BOSTON, MASSACHUSETTS 02111
                               TEL: (617) 542-6000
                               FAX: (617) 542-2241

         APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: As
soon as practical after this Registration Statement becomes effective.

         If the only securities being registered on this Form are being offered
pursuant to dividend or interest reinvestment plans, please check the following
box. [ ]

         If any of the securities being registered on this Form are to be
offered on a delayed or continuous basis pursuant to Rule 415 under the
Securities Act of 1933 other than securities offered only in connection with
dividend or interest reinvestment plans, check the following box. [X]

         If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering. [ ]

         If this Form is a post-effective amendment filed pursuant to Rule
462(c) under the Securities Act, check the following box and list the Securities
Act registration statement number of the earlier effective registration
statement for the same offering. [ ]

         If delivery of the prospectus is expected to be made pursuant to Rule
434, please check the following box. [ ]

The Registrant hereby amends this Registration Statement on such date or dates
as may be necessary to delay its effective date until the Registrant shall file
a further amendment which specifically states that this registration statement
shall thereafter become effective in accordance with Section 8(a) of the
Securities Act of 1933 or until the Registration Statement shall become
effective on such date as the Commission, acting pursuant to said Section 8(a),
may determine.




The information in this prospectus is not complete and may be changed. A
Registration Statement relating to these securities has been filed with the
Securities and Exchange Commission. No one may sell these securities nor may
offers to buy be accepted until the Registration Statement filed with the
Securities and Exchange Commission is effective. This prospectus is not an
offer to sell these securities and is not soliciting an offer to buy these
securities in any state where the offer, solicitation or sale is not
permitted.


                   SUBJECT TO COMPLETION, DATED DECEMBER 20, 2002


PROSPECTUS

                                5,000,000 SHARES


                               EPIX MEDICAL, INC.

                                  COMMON STOCK

         This prospectus will allow us to issue common stock over time. This
means:

     o   We will provide a prospectus supplement each time we issue common
         stock;

     o   The prospectus supplement will inform you about the specific terms of
         that offering and also may add, update or change information contained
         in this document;

     o   You should read this document and any prospectus supplement carefully
         before you invest.



         Our common stock is listed on the Nasdaq National Market under the
symbol "EPIX." On December 18, 2002, the last reported sale price of our
common stock on the Nasdaq National Market was $7.05 per share.


                   -------------------------------------------

                   INVESTING IN OUR SECURITIES INVOLVES RISKS.
                          SEE "RISK FACTORS" ON PAGE 4.

                   -------------------------------------------

Neither the Securities and Exchange Commission nor any state securities
commission has approved or disapproved of these securities or passed upon the
adequacy or accuracy of this prospectus. Any representation to the contrary is a
criminal offense.




                 The Date of this Prospectus is December  , 2002






                                TABLE OF CONTENTS

                                                                         Page
About This Prospectus....................................................  1
Business ................................................................  1
Risk Factors.............................................................  4
Cautionary Note On Forward-Looking Statements............................ 17
Use of Proceeds.......................................................... 18
Plan of Distribution..................................................... 19
Legal Matters............................................................ 21
Experts.................................................................. 21
Where You Can find More Information...................................... 21
Incorporation Of Documents By Reference.................................. 22


                                       i






                              ABOUT THIS PROSPECTUS

The following is only a summary. We urge you to read the entire prospectus,
including the more detailed financial statements, notes to the financial
statements and other information incorporated by reference from our other
filings with the Securities and Exchange Commission, or SEC. Investing in our
common stock involves risk. Therefore, carefully consider the information
provided under the heading "Risk Factors" beginning on page 4.

                                    BUSINESS

We are a leading developer of targeted contrast agents, which are substances
injected into blood vessels to improve the visual images produced by magnetic
resonance imaging, or MRI. MRI is a technique widely used in the
identification of a variety of diseases. It is a non-invasive procedure that
does not disturb body tissue and provides 3-dimensional images of, among
other things, the body's arteries and veins, collectively known as the
vascular system, that enable physicians to diagnose and manage disease. Our
principal product under development, MS-325, is designed to provide visual
imaging of multiple diseases of the heart and blood vessels, including
diseases of the blood vessels outside the heart, known as peripheral vascular
disease, as well as diseases that affect the coronary arteries and reduce
blood flow to the heart. Our primary target indication for MS-325 is
peripheral vascular disease. We believe that MS-325 will significantly
enhance the quality of MRI and provide physicians with a clinically superior,
minimally-invasive and cost-effective method for diagnosing peripheral
vascular disease. We also believe that MS-325 will simplify, and, in many
cases replace, X-ray angiography, a highly invasive and expensive
catheter-based procedure currently used for the detection of peripheral
vascular disease. We are currently in Phase III clinical trials to test the
safety and efficacy of MS-325 enhanced magnetic resonance angiography, or
MRA, which is a type of MRI that is specific to the vascular system. We
believe that magnetic resonance angiography will be a less invasive method of
imaging and determining a patient's internal blood vessel anatomy for the
evaluation of peripheral vascular disease.

The use of MRI has grown steadily over the past 10 years due to reduced cost
and improved imaging capabilities. MRI now provides an effective method of
diagnosis for a broad range of applications. MRI manufacturers have improved
both their hardware and software, reducing the time per procedure
dramatically, while significantly enhancing image resolution. While MRI is
currently used extensively to image many organs and tissues in the body, its
use in imaging the vascular system has been limited. Prior attempts to employ
contrast agents to make such vascular MRI more useful as a diagnostic tool
have had limited success. Unlike most currently available non-specific MRI
contrast agents, MS-325 is specifically designed to



                                      1





enhance the quality of magnetic resonance images of the arteries and veins
and provide physicians with a superior method for diagnosing diseases in
these vessels. MS-325 is a small molecule, which produces an MRI signal
because of the presence of gadolinium, a magnetically active element favored
by clinicians for enhancing magnetic resonance images. This molecule is
designed with our proprietary technology to bind to albumin, the most common
protein in the blood. In MS-325-enhanced images generated with standard MRI
techniques, the blood produces a strong magnetic signal and appears bright
against the dark background of surrounding tissue. Because of its attraction
to albumin, MS-325 remains at high concentrations in the bloodstream
throughout the MRI exam and therefore provides the extended image time and
signal strength required to obtain a high contrast, high resolution image of
the vascular system. Like most currently available non-specific contrast
agents, MS-325 is designed to be excreted safely through the kidneys over
time.

We have entered into strategic alliances with Schering Aktiengesellschaft, or
Schering AG, and Tyco International Ltd., formerly Mallinckrodt, Inc., and
referred to here as Tyco/Mallinckrodt, for the development, manufacture and
commercialization of MS-325 and other vascular contrast agents. We have also
formed collaborations with the three leading MRI scanner manufacturers, General
Electric Medical Systems, Philips Medical Systems and Siemens Medical Systems to
develop advanced imaging techniques and tools designed to facilitate the use of
MS-325-enhanced magnetic resonance angiography.

Although we are seeking to develop another targeted contrast agent that would
enable MRI to illuminate blood clots as described in more detail below, MS-325
is currently our only product candidate in human clinical trials. Our initial
commercial product revenues and profits will depend on the successful completion
of our Phase III clinical trials, Food and Drug Administration, or FDA,
approval of MS-325, the successful manufacturing of the product by our partner
Tyco/Mallinckrodt and sales by our partner Schering AG.

As noted above, and as part of our thrombus program, we are seeking to develop
a targeted contrast agent in addition to MS-325 that would enable MRI to
illuminate blood clots. Such a product could potentially change the method of
diagnosis for many of the conditions associated with the formation of blood
clots in the arteries and veins. The most common form of these conditions is
deep vein thrombosis, which is characterized by the presence of blood clots
in the deep veins of the leg and calf. The most severe consequences of deep
vein thrombosis is pulmonary embolism, which tends to occur when a blood clot
dislodges from the vessel wall to obstruct the arteries in the lung. We
believe that the illumination of blood clots by a targeted contrast agent
used in conjunction with MRI could lead to better medical outcomes due to
earlier and more definitive diagnosis. Early diagnosis is especially
important for clots in the thigh, pelvis and vena cava, which can be fatal
because of their increased likelihood of migrating to the lungs. We believe
that such a contrast agent could eliminate the need for procedures that
require the use of large quantities of X-ray contrast dye and expose patients
to radiation, diagnostic tests that use radioactive drugs and ultra sound,
which are all currently used to identify blood clots in the veins and
arteries. We further believe that our proprietary technology could enable MRI
to differentiate old and new clot formation, thereby potentially identifying
those clots that



                                      2





pose the most risk to patients. In November 1999, we announced that our
prototype agent, EP-862, had been shown in pre-clinical testing to detect
sub-millimeter blood clots in animals. Although we are unlikely to develop
EP-862 as a thrombus agent, we have continued to advance the thrombus program
by identifying several other improved prototype agents. We expect to continue
to apply resources to the thrombus program in the future and hope to file an
Investigational New Drug application, or IND, with the FDA, which, if
approved, will allow us to begin human safety trials.

We incorporated in Delaware in 1988 and commenced operations in 1992. Our
principal executive offices are located at 71 Rogers Street, Cambridge,
Massachusetts 02142-1118 and our telephone number is (617) 250-6000. Our Web
site is located at http://www.epixmed.com. We do not intend for the information
contained in our Web site to be considered a part of this prospectus.



                                       3





RISK FACTORS

         AN INVESTMENT IN OUR COMMON STOCK INVOLVES A HIGH DEGREE OF RISK. YOU
SHOULD CAREFULLY CONSIDER THE FOLLOWING RISK FACTORS, OTHER INFORMATION INCLUDED
IN THIS PROSPECTUS, ANY SUPPLEMENT TO THIS PROSPECTUS AND INFORMATION IN OUR
PERIODIC REPORTS FILED WITH THE SEC. IF ANY OF THE FOLLOWING RISKS ACTUALLY
OCCUR, OUR BUSINESS, FINANCIAL CONDITION OR RESULTS OF OPERATIONS COULD BE
MATERIALLY AND ADVERSELY AFFECTED, AND YOU MAY LOSE SOME OR ALL OF YOUR
INVESTMENT.

WE HAVE NEVER GENERATED REVENUES FROM COMMERCIAL SALES OF OUR PRODUCTS AND, IF
MS-325 DOES NOT RECEIVE APPROVAL FROM THE FOOD AND DRUG ADMINISTRATION, WE WILL
HAVE NO PRODUCTS TO MARKET IN THE FORESEEABLE FUTURE.

         We currently have no products for sale, and we cannot guarantee that we
will ever have marketable products. MS-325 is currently our only product
candidate in human clinical trials, and we cannot be certain that any of our
other development projects will yield a product candidate suitable for entry
into clinical trials. As a result, our initial revenues and profits from
commercial sales of our products, if any, will be derived from sales of MS-325.
If MS-325 fails to achieve regulatory approval and market acceptance, and if we
do not succeed in bringing any of our other product candidates to human clinical
trials and achieve regulatory approval and market acceptance for them, our
business will fail and as a result, you may lose all or part of your investment.

         To date, we have received revenues from payments made under licensing,
royalty arrangements, product development and marketing agreements with
strategic collaborators. In particular, our revenue for the year ended December
31, 2001 was $9.6 million, and consisted of $5.7 million from the product
development portion of our strategic collaboration agreement with Schering AG,
$2.1 million from a patent licensing and royalty agreement entered into with
Bracco Imaging, S. p. A. and $1.8 million of license fee revenue related to the
strategic collaboration agreements for the development and marketing of MS-325
with Schering AG and Tyco/Mallinckrodt. In addition to these sources of revenue,
we have financed our operations to date through public stock offerings, private
sales of equity securities and equipment lease financings.

         Although we are currently in compliance with the terms of our strategic
collaboration agreements, the revenues derived from them are subject to
fluctuation in timing and amount. We may not receive anticipated revenue under
our existing collaboration or licensing agreements and, additionally, these
agreements may be terminated upon certain circumstances. Therefore, to achieve
profitable and sustainable operations, we, alone or with others, must
successfully develop, obtain regulatory approval for, introduce, market and sell
products. We do not expect to receive revenue from the sale of any of our
product candidates for the next several years because we may not:

o        successfully complete our product development efforts;

o        obtain required regulatory approvals in a timely manner, if at all;



                                       4





o        manufacture our product candidates at an acceptable cost and with
         acceptable quality; or

o        successfully market any approved products.

As a result, we may never generate revenues from sales of our product candidates
and our failure to generate positive cash flow could cause our business to fail.

WE ANTICIPATE FUTURE LOSSES AND MAY NEVER BECOME PROFITABLE.

         Our future financial results are uncertain. We have experienced
significant losses since we commenced operations in 1992. Our accumulated net
losses as of September 30, 2002 were approximately $109 million. These losses
have primarily resulted from expenses associated with our research and
development activities, including preclinical and clinical trials, and
general and administrative expenses. We anticipate that our research and
development expenses will increase significantly in the future, and we expect
to incur substantial losses over at least the next several years as we expand
our research and development efforts, pre-clinical testing and clinical
trials and we implement manufacturing, marketing and sales programs. As a
result, we cannot predict when we will become profitable, if at all, and if
we do, we may not remain profitable for any substantial period of time. If we
fail to achieve profitability within the time frame expected by investors,
the market price of our common stock may decline and consequently our
business may not be sustainable.

IF THE MARKET DOES NOT ACCEPT OUR TECHNOLOGY AND PRODUCTS, WE MAY NOT GENERATE
SUFFICIENT REVENUES TO ACHIEVE OR MAINTAIN PROFITABILITY.

         The commercial success of MS-325 and our other product candidates,
when and if approved for marketing by the FDA and corresponding foreign
agencies, depends on their acceptance by the medical community and third
party payors as clinically useful, cost-effective and safe. While contrast
agents are currently used in an estimated 25% to 30% of all MRI exams, there
are no FDA approved targeted vascular agents in use. Furthermore, clinical
use of MRI for vascular imaging has been limited and use of MRI for
peripheral vascular disease imaging has occurred mainly in research. Market
acceptance, and thus sales of our product candidates, will depend on several
factors, including:

         o        safety;

         o        price;

         o        ease of administration;

         o        effectiveness; and

         o        the rate of adoption of up-to-date MRI technology.

         Market acceptance will also depend on our ability and that of our
strategic partners to educate the medical community and third party payors about
the benefits of diagnostic imaging with MRI enhanced with MS-325 compared to
imaging with other technologies. MS-325 represents a new approach to imaging the
peripheral vascular system, and market acceptance both of MRI as an appropriate
imaging technique for the peripheral vascular system, and of MS-325, is critical
to our success. If MS-325 or any of our other products do not achieve market
acceptance, we may not generate sufficient revenues to achieve or maintain
profitability.



                                       5





IF WE DO NOT RAISE ADDITIONAL FUNDS NECESSARY TO FUND OUR OPERATIONS, WE MAY NOT
BE ABLE TO IMPLEMENT OUR BUSINESS PLAN.

         Since inception, we have funded our operations primarily through our
public offerings of common stock, private sales of equity securities, equipment
lease financings and royalty and license payments from our strategic partners.
We believe that we will need to raise substantial additional funds for research,
development and other expenses, through equity or debt financings, strategic
alliances or otherwise, prior to commercialization of any of our product
candidates. Our future liquidity and capital requirements will depend upon
numerous factors, including the following:

         o        the progress and scope of clinical trials;

         o        the timing and costs of filing future regulatory submissions;

         o        the timing and costs required to receive both United States
                  and foreign governmental approvals;

         o        the cost of filing, prosecuting, defending and enforcing
                  patent claims and other intellectual property rights;

         o        the extent to which our products gain market acceptance;

         o        the timing and costs of product introductions;

         o        the extent of our ongoing research and development programs;

         o        the costs of training physicians to become proficient with the
                  use of our products; and

         o        the costs of developing marketing and distribution
                  capabilities.

         We estimate that existing cash, cash equivalents and marketable
securities will be sufficient to fund our operations through November 2003. We
believe that we will need to raise additional funds for research, development
and other expenses through equity or debt financing, strategic alliances or
otherwise, in order to achieve commercial introduction of any of our product
candidates. Additional funding may not be available to us on favorable terms, if
at all. Debt financing, if available, may involve covenants which could restrict
our business activities. To the extent that we raise additional capital through
the sale of equity or securities convertible into equity, the issuance of such
securities could result in dilution to our existing stockholders. If we are
unable to raise additional funds through equity or debt financing when needed,
we may be required to enter into arrangements with strategic partners or others
that may require us to relinquish rights to certain of our technologies, product
candidates, products or potential markets. If we are required to relinquish such
rights, the ultimate value of these product candidates to us may be reduced.


WE HAVE A LIMITED MANUFACTURING CAPABILITY AND WE INTEND TO RELY ON OUTSOURCED
MANUFACTURING TO PRODUCE MS-325.

         We do not have, nor do we currently have plans to develop,
full-scale manufacturing capability for MS-325. While we do manufacture small
amounts of MS-325 for research and



                                       6






development efforts, we intend to rely on Tyco/Mallinckrodt as the primary
manufacturer of MS-325 for Phase III clinical trials, as well as for any
future human clinical trials and commercial use. In the event that
Tyco/Mallinckrodt fails to fulfill its manufacturing responsibilities
satisfactorily, Schering AG has the right to purchase MS-325 from a third
party or to manufacture the compound itself. However, either course of action
could materially delay the manufacture and development of MS-325. Schering AG
may not be able to find an alternative manufacturer. In addition, Schering AG
may not be able to manufacture MS-325 itself in a timely manner. If we
experience a delay in manufacturing, it could result in a delay in the
approval or commercialization of MS-325 and have a material adverse effect on
our business, financial condition and results of operations.

IF MRI MANUFACTURERS ARE NOT ABLE TO ENHANCE THEIR HARDWARE AND SOFTWARE, WE
WILL NOT BE ABLE TO COMPLETE DEVELOPMENT OF OUR CONTRAST AGENT FOR THE
EVALUATION OF CARDIAC INDICATIONS.

         Although magnetic resonance imaging hardware and software is
sufficient for the evaluation of peripheral vascular disease, which is our
primary target indication, we believe that the technology is not as advanced
for cardiac applications, which will be our next target indication. Our
initial NDA filing for MS-325 will be related to peripheral vascular disease.
Peripheral vascular disease, as it relates to our primary target indication,
occurs in areas of the body where imaging sequences on scanners currently
allow for the use of MS-325-enhanced magnetic resonance angiography for
diagnostic purposes, which covers the entire body's vascular system, except
for the heart. Based on feasibility studies we have conducted, however, the
imaging technology available for cardiac applications, including coronary
angiography and cardiac perfusion imaging, is not developed to the point
where there is clear visualization of the cardiac region, due to the effects
of motion from the beating of the heart. Although not our primary focus, we
plan to continue to conduct feasibility studies for cardiac indications using
available software and hardware that can be adopted for coronary and cardiac
perfusion data acquisition. We have entered into research collaborations with
General Electric Medical Systems and Phillips Medical Systems that include
development and optimization of cardiac imaging sequences with contrast
agents like MS-325. We have also collaborated with a number of leading
academic institutions to help optimize cardiac imaging with MS-325. While
significant progress has been made in developing these clinical applications
for cardiac imaging, we do not know when, or if, these techniques will enable
MS-325 to provide clinically relevant images in cardiac indications. If MRI
product manufacturers are not able to enhance their scanners to perform
cardiac indications, we will not be able to complete our development
activities of MS-325 for that application, thereby reducing the potential
market for a product in this area.

OUR COMPETITORS MAY HAVE GREATER FINANCIAL RESOURCES, SUPERIOR PRODUCTS OR
PRODUCT CANDIDATES, MANUFACTURING CAPABILITIES AND/OR MARKETING EXPERTISE, AND
WE MAY NOT BE ABLE TO COMPETE WITH THEM SUCCESSFULLY.

         Medical technology is subject to intense competition and rapid
technological change. We have many competitors, including pharmaceutical,
biotechnology and chemical companies, a number of which, including our
strategic partners, are actively developing and marketing products that could
compete with our product candidates. Specifically, although there are no
FDA-approved targeted vascular contrasts agents for use with MRI, there are a
number of non-specific MRI agents approved for marketing in the United States
and certain foreign markets that are likely to compete with MS-325 if MS-325
is approved for Magnetic Resonance Angiography or MRA. Collectively, these
non-specific agents are referred to as "extracellular" agents, and include:
Magnevist(R) by Schering AG, Dotarem(R) by Guerbet, S.A., Omniscan(R) by
Amersham Health, ProHance(R) by Bracco Imaging S.p.A. and OptiMark(R) by
Tyco/Mallinckrodt. Extracellular agents are broadly-accepted in the market as
general purpose



                                       7





MRI agents. None of these agents is currently approved by the FDA for MRA,
but their use in applications outside of the primary indication described in
the product labeling is increasing and could present significant adoption
hurdles for MS-325 if such use becomes entrenched in the marketplace.
Additionally, we believe that some of these general purpose agents are in
clinical trials for an MRA indication. However, these general purpose agents
are not specifically designed for vascular imaging and because they "leak"
out of the vessels into the extracellular space, they do not provide the
extended imaging window associated with MS-325. In addition, we are aware of
five agents under clinical development, specifically for use with MRA:
Schering AG's Gadomer-17 and SHU555C, Guerbet's P792 (Vistarem), Bracco's
B-22956/1 and Advanced Magnetic's Code 7228. Public information on the status
of clinical development and performance characteristics for these agents is
limited. However, many of these competitors have substantially greater
capital and other resources than we do and may represent significant
competition for us. These companies may succeed in developing technologies
and products that are more effective or less costly than any of those that we
may develop. In addition, these companies may be more successful than we are
in developing, manufacturing and marketing products.

         Moreover, there are several well-established medical imaging methods
that currently compete and will continue to compete with MRI, including Digital
Subtraction, or DSA, X-ray angiography, CT angiography, nuclear medicine and
ultrasound, and there are companies that are actively developing the
capabilities of these competing methods to enhance their effectiveness in
cardiovascular system imaging. DSA is currently considered the clinical gold
standard for cardiovascular angiography, but all methods offer advantages and
disadvantages, which are described in the following table:




--------------------------------------------------------------------------------------------------------
                              Advantages                          Disadvantages
--------------------------------------------------------------------------------------------------------
                                                          
MRI                           o   3-dimensional images            o   Requires high level of
                              o   Minimally-invasive                  training
                              o   Favorable safety profile        o   Inadvisable for patients
                              o   High quality images                 with certain conditions (i.e.
                                                                      pacemakers, etc.)
                                                                  o   Less widely available
--------------------------------------------------------------------------------------------------------
CT Angiography                o   Rapid and easy data             o   Radiation
                                  acquisition                     o   Varying levels of toxicity
                                                                  o   Calcium and bone artifacts
                                                                  o   Time consuming
                                                                      post-processing
--------------------------------------------------------------------------------------------------------
DSA                           o   Significant clinical            o   Invasive
(X-ray Angiography)               experience                      o   Radiation
                              o   Opportunity to treat in         o   Varying levels of toxicity
                                  same procedure                  o   Significant safety risks
                              o   Highest resolution              o   2-dimensional images
                                                                  o   Expensive
                                                                  o   Patient recuperation time
--------------------------------------------------------------------------------------------------------
Ultrasound                    o   Low cost                        o   Operator dependent
                              o   Fast                            o   Lack of anatomic detail
                              o   Widely available                o   Bone precludes use in many
                              o   Non-invasive                        vascular beds
                                                                  o   Inability to visualize
                                                                      small vessels
--------------------------------------------------------------------------------------------------------




                                       8





         We cannot guarantee that we will be able to compete successfully in the
future, or that developments by others will not render MS-325 or our future
product candidates obsolete or non-competitive, or that our collaborators or
customers will not choose to use competing technologies or products. Any
inability to compete successfully on our part will have a materially adverse
impact on our operating results.

WE CURRENTLY DEPEND ON OUR STRATEGIC COLLABORATORS FOR SUPPORT IN PRODUCT
DEVELOPMENT AND THE REGULATORY APPROVAL PROCESS, AND, IN THE FUTURE, MAY DEPEND
ON THEM FOR PRODUCT MARKETING SUPPORT AS WELL. THESE EFFORTS MAY SUFFER IF WE
EXPERIENCE PROBLEMS WITH OUR COLLABORATORS.

         We depend on strategic collaborators for support in product development
and the regulatory approval process as well as a variety of other activities
including manufacturing, marketing and distribution of our products in the
United States and abroad, when, and if, the FDA and corresponding foreign
agencies approve our product candidates for marketing. To date, we have entered
into strategic alliances and collaborations with Schering AG, Tyco/Mallinckrodt,
General Electric Medical Systems, Philips Medical Systems and Siemens Medical
Systems. Two of our key agreements include a collaboration agreement with
Schering AG, to develop and commercialize MS-325 and other MRI vascular
agents worldwide, and an agreement with Tyco/Mallinckrodt, granting
Tyco/Mallinckrodt rights to enter into an agreement with Schering AG to
manufacture MS-325 for clinical development and commercial use. We may not
receive milestone payments from these alliances should MS-325 fail to meet
certain performance targets in clinical trials. Further, our receipt of
revenues from strategic alliances is affected by the level of efforts of our
collaborators. Our collaborators may not devote the resources necessary to
complete development, and commence marketing, of MS-325 in their respective
territories, or they may not successfully market MS-325. In addition,
Schering AG and Tyco/Mallinckrodt currently manufacture imaging agents for
other technologies that will compete against MS-325 and Schering AG will be
responsible for setting the price of the product worldwide. However, Schering
AG may not set prices in a manner that maximizes revenues for us. We are
currently in compliance with the terms of these agreements, and although we
are currently in Phase III clinical trials, our failure to receive future
milestone payments, or a reduction or discontinuance of efforts by our
partners would have a material adverse effect on our business, financial
condition and results of operations.

         Furthermore, our collaboration agreement with Schering AG may be
terminated early under certain circumstances, including if there is a
material breach of the agreement by either of us. In addition, we intend to
seek additional collaborations with third parties, who may negotiate
provisions that allow them to terminate their agreements with us prior to the
expiration of the negotiated term under certain circumstances. If Schering AG
or any other third party collaborator



                                       9





were to terminate its agreement with us or otherwise fail to perform its
obligations under our collaboration or to complete them in a timely manner,
we could lose significant revenue. If we are unable to enter into future
strategic alliances with capable partners on commercially reasonable terms,
we may delay the development and commercialization of future product
candidates and could possibly postpone them indefinitely.

WE DEPEND ON EXCLUSIVELY LICENSED TECHNOLOGY FROM THE MASSACHUSETTS GENERAL
HOSPITAL AND IF WE LOSE THIS LICENSE, IT IS UNLIKELY WE COULD OBTAIN THIS
TECHNOLOGY ELSEWHERE, WHICH WOULD HAVE A MATERIAL ADVERSE EFFECT ON OUR
BUSINESS.

         Under the terms of a license agreement that we have with Massachusetts
General Hospital, or MGH, we are the exclusive licensee to certain technology,
including patents and patent applications, which relate to our product
candidates, including MS-325. The license agreement imposes various
commercialization, sublicensing, royalty and other obligations on us. If we fail
to comply with these and other requirements our license could convert from
exclusive to nonexclusive or terminate entirely. It is unlikely that we would be
able to obtain this technology elsewhere. Any such event would mean that we
would be unlikely to produce our product candidates, including MS-325, and would
therefore have a material adverse effect on our business, financial condition
and results of operations. Currently, we are in compliance with the terms of the
license agreement, and we do not have any reason to believe that this license
may be terminated.

WE DEPEND ON PATENTS AND OTHER PROPRIETARY RIGHTS, AND IF THEY FAIL TO PROTECT
OUR BUSINESS, WE MAY NOT BE ABLE TO COMPETE EFFECTIVELY.

         The protection of our proprietary technologies is material to our
business prospects. We pursue a comprehensive patent program for our product
candidates in the United States and in other countries where we believe that
significant market opportunities exist. We own or have an exclusive license
to patents and patent applications on the critical aspects of our core
technology as well as many specific applications of this technology.
Specifically, patents and patent applications related to our core technology
consist of two U.S. patents that are exclusively licensed to us from MGH, as
well as their counterpart patents and applications in foreign countries; two
U.S. patents and their counterpart patents and applications in foreign
countries that we own; eight patent applications and six provisional patent
applications on fourteen different subject matters as well as their
counterpart patents and applications in foreign countries. One of our issued
patents covers the process by which MS-325 is manufactured. Even though we
hold these patents and have made these patent applications, because the
patent positions of pharmaceutical and biopharmaceutical firms, including
ours, generally include complex legal and factual questions, our patent
position remains uncertain. For example, because patent applications in the
United States with foreign counterparts and foreign applications are
maintained in secrecy until patents are issued or published, and patent
applications in foreign countries are maintained in secrecy for a specified
period after filing, we cannot be certain that the named applicants or
inventors of the subject matter covered by our patent applications or
patents, whether directly owned or licensed to us, were the first to invent
or the first to file patent applications for such inventions. Third parties
may oppose, challenge, infringe upon, circumvent or seek to invalidate
existing or future patents owned by or licensed to us. A court or other



                                       10





agency with jurisdiction may find our patents invalid, not infringed or
unenforceable and we cannot be sure that patents will be granted with respect
to any of our pending patent applications or with respect to any patent
applications filed by us in the future. Even if we have valid patents, these
patents still may not provide sufficient protection against competing
products or processes. If we are unable to successfully protect our
proprietary methods and technologies, or, if our patent applications do not
result in issued patents, we may not be able to prevent other companies from
practicing our technology and, as a result, our competitive position would be
harmed.

WE MAY NEED TO INITIATE LAWSUITS TO PROTECT OR ENFORCE OUR PATENTS AND OTHER
INTELLECTUAL PROPERTY RIGHTS, WHICH COULD INCUR SUBSTANTIAL COSTS, AND WHICH
COULD RESULT IN THE FORFEITURE OF THESE RIGHTS.

         We may need to bring costly and time-consuming litigation against third
parties in order to enforce our issued patents, protect our trade secrets and
know how, or to determine the enforceability, scope and validity of proprietary
rights of others. In addition to being costly and time-consuming, such lawsuits
could divert management's attention from other business concerns. These lawsuits
could also result in the invalidation or a limitation in the scope of our
patents or forfeiture of the rights associated with our patents or pending
patent applications. We may not prevail and a court may find damages or award
other remedies in favor of an opposing party in any such lawsuits. During the
course of these suits, there may be public announcements of the results of
hearings, motions and other interim proceedings or developments in the
litigation. Securities analysts or investors may perceive these announcements to
be negative, which could cause the market price of our stock to decline. In
addition, the cost of such litigation could have a material adverse effect on
our business and financial condition.

OTHER RIGHTS AND MEASURES THAT WE RELY UPON TO PROTECT OUR INTELLECTUAL PROPERTY
MAY NOT BE ADEQUATE TO PROTECT OUR PRODUCTS AND SERVICES AND COULD REDUCE OUR
ABILITY TO COMPETE IN THE MARKET.

         In addition to patents, we rely on a combination of trade secrets,
copyright and trademark laws, nondisclosure agreements and other contractual
provisions and technical measures to protect our intellectual property rights.
While we require employees, collaborators, consultants and other third parties
to enter into confidentiality and/or non-disclosure agreements where
appropriate, any of the following could still occur:

         o        the agreements may be breached;

         o        we may have inadequate remedies for any breach;

         o        proprietary information could be disclosed to our competitors;
                  or

         o        others may independently develop substantially equivalent
                  proprietary information and techniques or otherwise gain
                  access to our trade secrets or disclose such technologies.

         If, for any of the above reasons, our intellectual property is
disclosed or misappropriated, it would harm our ability to protect our rights
and our competitive position. Moreover, several of our management and
scientific personnel were formerly associated with other pharmaceutical



                                       11





and biotechnology companies and academic institutions. In some cases, these
individuals are conducting research in similar areas with which they were
involved prior to joining us. As a result, we, as well as these individuals,
could be subject to claims of violation of trade secrets and similar claims.

OUR SUCCESS WILL DEPEND PARTLY ON OUR ABILITY TO OPERATE WITHOUT INFRINGING THE
INTELLECTUAL PROPERTY RIGHTS OF OTHERS, AND IF WE ARE UNABLE TO DO SO, WE MAY
NOT BE ABLE TO SELL OUR PRODUCTS.

         Our commercial success will depend, to a significant degree, on our
ability to operate without infringing upon the patents of others in the United
States and abroad. There may be pending or issued patents, held by parties not
affiliated with us, relating to technologies we use in the development or use of
certain of our contrast agents. If any judicial or administrative proceeding
upholds any third party patents as valid and enforceable, we could be prevented
from practicing the subject matter claimed in such patents, or would be required
to obtain licenses from the owners of each such patent, or to redesign our
products or processes to avoid infringement. If we are unable to obtain a
required license on acceptable terms, or are unable to design around any third
party patent, we may be unable to sell our products, which would have a material
adverse effect on our business.

EXTENSIVE GOVERNMENT REGULATION MAY DELAY OR PREVENT US FROM MARKETING MS-325 OR
OUR OTHER PRODUCTS UNDER DEVELOPMENT.

         We are subject to extensive U.S. and foreign governmental regulatory
requirements and lengthy approval processes for our product candidates. The
development and commercial use of our product candidates will be regulated by
numerous federal, state, local and foreign governmental authorities in the U.S.,
including the FDA and foreign regulatory agencies abroad. The nature of our
research and development and manufacturing processes requires the use of
hazardous substances and testing on certain laboratory animals. Accordingly, we
are subject to extensive federal, state and local laws, rules, regulations and
policies governing the use, generation, manufacture, storage, air emission,
effluent discharge, handling and disposal of certain materials and wastes, as
well as the use of and care for laboratory animals. Although we believe we are
in compliance with all such laws and maintain policies and procedures to ensure
that we remain in compliance, if we fail to comply or if an accident occurs, we
may be exposed to legal risk and be required to pay significant penalties or be
held liable for any damages that result. Such liability could exceed our
financial resources. Furthermore, current laws could change and new laws could
be passed that may force us to change our policies and procedures, an event
which could impose significant costs on us.

         Specifically, MS-325 is regulated by the FDA as a pharmaceutical
product. The FDA has established substantial requirements for the research,
development, manufacture and marketing of pharmaceutical products. The process
required by the FDA before MS-325 and our other product candidates may be
marketed in the U.S. typically involves the performance of preclinical
laboratory and animal tests; submission of an investigational new drug
application or IND; completion of human clinical trials; submission of a new
drug application, or NDA, to the FDA; and FDA approval of the NDA.



                                       12





         This regulatory approval process is lengthy and expensive. Although
some of our employees have experience in obtaining regulatory approvals, we
have only limited experience in filing or pursuing applications necessary to
gain regulatory approvals. Preclinical testing of our product development
candidates is subject to Good Laboratory Practices as prescribed by the FDA
and the manufacture of any products developed by us will be subject to Good
Manufacturing Practices as prescribed by the FDA. We may not obtain the
necessary FDA clearances and subsequent approvals in a timely manner, if at
all. We can not be sure as to the length of the clinical trial period or the
number of patients that will be required to be tested in the clinical trials
in order to establish the safety and efficacy of MS-325 or any of our future
product candidates. Our clinical trials may not be successful, and we may not
complete them in a timely manner. We could report serious side effects as the
clinical trials proceed. Our results from early clinical trials may not
predict results that we obtain in large-scale clinical trials, even after
promising results in earlier trials. The rate of completion of our clinical
trials depends upon, among other things, the rate of patient enrollment.
Patient enrollment is a function of many factors, including the size of the
patient population, the nature of the clinical protocol under which MS-325 is
studied, the proximity of the patient to a clinical site and the eligibility
criteria for the study. Furthermore, we, the FDA or other regulatory
authorities may alter, suspend or terminate clinical trials at any time. For
example, in September 2001, after discussions with the FDA, we expanded our
initial target indication for MS-325 from one specific body region, the
aortoiliac region, to a broader indication that includes the entire body's
peripheral vascular system, except for the heart. This expansion required us
to add two new clinical trials to our then existing Phase III clinical trial
program, one to determine the efficacy of MS-325 enhanced MRA for the
detection of peripheral vascular disease in the renal (kidney) arteries, and
another to determine the efficacy of MS-325 enhanced MRA for the detection of
peripheral vascular disease in the pedal (feet) arteries. Although providing
us with greater market potential for the sale of MS-325 upon approval, we
expect that this change to our Phase III clinical trial program, and the
associated delay in the start up of new clinical centers, will result in an
approximate fifteen month delay to our NDA submission date from our previous
forecast, and an increase in costs associated with the program. If we do not
successfully complete our Phase III clinical trial program, we will not have
a product to market.

         In addition, we may encounter unanticipated delays or significant costs
in our efforts to secure necessary approvals. We may not obtain regulatory
approval, even after the performance of clinical trials and the passage of time
and the expenditure of such resources, for MS-325 or any other product
candidates that we develop. Our analysis of data obtained from preclinical and
clinical activities is subject to confirmation and interpretation by regulatory
authorities, which could delay, limit or prevent FDA regulatory approval. Delays
in obtaining government regulatory approval could adversely affect our marketing
as well as our ability to generate significant revenues from commercial sales.

         Future United States legislative or administrative actions also
could prevent or delay regulatory approval of our product candidates. Even if
we obtain regulatory approvals, they may include significant limitations on
the indicated uses for which we may market a product. A marketed product also
is subject to continual FDA and other regulatory agency review and
regulation. Later discovery of previously unknown problems or failure to
comply with the



                                      13





applicable regulatory requirements may result in restrictions on the
marketing of a product or withdrawal of the product from the market, as well
as possible civil or criminal sanctions. Further, many academic institutions
and companies conducting research and clinical trials in the MRI contrast
agent field are using a variety of approaches and technologies. If
researchers obtain any adverse results in preclinical studies or clinical
trials, it could adversely affect the regulatory environment for MRI contrast
agents generally. In addition, if we obtain marketing approval, the FDA may
require post marketing testing and surveillance programs to monitor the
product's efficacy and side effects. Results of these post-marketing programs
may prevent or limit the further marketing of the monitored product. If we
cannot successfully market our products, we will not generate sufficient
revenues to achieve or maintain profitability.

         Our strategic partners and we are also subject to numerous and varying
foreign regulatory requirements governing the design and conduct of clinical
trials and the manufacturing and marketing of our products. The foreign
regulatory approval process may include all of the risks associated with
obtaining FDA approval set forth above, and we may not obtain foreign regulatory
approvals on a timely basis, if at all, thereby compromising our ability to
market our products abroad.

PRODUCT LIABILITY CLAIMS COULD INCREASE OUR COSTS AND ADVERSELY AFFECT OUR
RESULTS OF OPERATIONS.

         The clinical testing, manufacturing and marketing of our product
candidates may expose us to product liability claims, and we may experience
material product liability losses in the future. We currently have limited
product liability insurance for the use of our product candidates in clinical
research, but our coverage may not continue to be available on terms acceptable
to us or adequate for liabilities we actually incur. We do not have product
liability insurance coverage for the commercial sale of our products but intend
to obtain such coverage if and when we commercialize our product candidates.
However, we may not be able to obtain adequate additional product liability
insurance coverage on acceptable terms, if at all. A successful claim brought
against us in excess of available insurance coverage, or any claim or product
recall that results in significant adverse publicity against us, may have a
material adverse effect on our business and results of operations.

IF WE FAIL TO GET ADEQUATE LEVELS OF REIMBURSEMENT FROM THIRD PARTY PAYORS FOR
OUR PRODUCT CANDIDATES AFTER THEY ARE APPROVED IN THE U.S. AND ABROAD, WE WILL
NOT BE ABLE TO COMMERCIALIZE OUR PRODUCT CANDIDATES.

         We could be adversely affected by changes in reimbursement policies
of governmental or private healthcare payors, particularly to the extent any
such changes affect reimbursement for procedures in which our product
candidates would be used. Failure by physicians, hospitals and other users of
our products to obtain sufficient reimbursement from third party payors for
the procedures in which our products would be used or adverse changes in
governmental and private third party payors' policies toward reimbursement
for such procedures would have a material adverse effect on our ability to
market our products and consequently it would have an adverse effect on our
business, financial condition and results of operations. If we obtain the
necessary foreign regulatory approvals, market acceptance of our product
candidates in international



                                     14





markets would be dependent, in part, upon the availability of reimbursement
within prevailing healthcare payment systems. Reimbursement and healthcare
payment systems in international markets vary significantly by country, and
include both government sponsored health care and private insurance. We
intend to seek international reimbursement approvals, although we cannot
assure you that any such approvals will be obtained in a timely manner, if at
all, and failure to receive international reimbursement approvals could have
an adverse effect on market acceptance of our products in the international
markets in which such approvals are sought.

WE DEPEND ON OUR KEY PERSONNEL, THE LOSS OF WHOM WOULD HURT OUR ABILITY TO
COMPETE.

         Our future business and operating results depend in significant part
upon the continued contributions of our senior management and key technical
personnel. If any such personnel were to be hired away from us by a competitor,
or if for any reason, they could not continue to work for us, we would have
difficulty hiring officers with equivalent skills in general, financial and
research management and our ability to achieve our business objectives or to
operate or compete in our industry may be seriously impaired. Although we
maintain key life insurance on the lives of some key officers, the loss of any
key employee, the failure of any key employee to perform in his or her current
position, or our inability to attract and retain skilled employees, as needed,
could have a material adverse effect on our business, financial condition and
results of operations. Our future business and operating results also depend in
significant part upon our ability to attract and retain qualified management,
operational and technical personnel. Competition for this personnel is intense,
and we may not be successful in attracting or retaining such personnel. If we
were to lose these employees to our competitors, we could spend a significant
amount of time and resources to replace them, which would impair our research
and development efforts.

OUR STOCK PRICE IS VOLATILE. IT IS POSSIBLE THAT YOU MAY LOSE ALL OR PART OF
YOUR INVESTMENT.

         The market prices of the capital stock of medical technology companies
have historically been very volatile, and the market price of the shares of our
common stock fluctuates. The market price of our common stock is affected by
numerous factors, including:

         o        actual or anticipated fluctuations in our operating results;

         o        announcements of technological innovation or new commercial
                  products by us or our competitors;

         o        new collaborations entered into by us or our competitors;

         o        developments with respect to proprietary rights, including
                  patent and litigation matters;

         o        results of pre-clinical and clinical trials;

         o        conditions and trends in the pharmaceutical and other
                  technology industries;

         o        adoption of new accounting standards affecting such
                  industries;

         o        changes in financial estimates by securities analysts; and

         o        degree of trading liquidity in our common stock and general
                  market conditions.

         During 2001, the closing price of our common stock ranged from
$14.60 to $6.24. Our common stock reached a high of $15.86 and traded as low
as $4.11 during the first three quarters



                                     15





of 2002. The last reported sales price for our common stock on December 18,
2002 was $7.05. If our stock price declines significantly, we may be unable
to raise additional capital. Significant declines in the price of our common
stock could also impede our ability to attract and retain qualified employees
and reduce the liquidity of our common stock.

         In addition, the stock market has from time to time experienced
significant price and volume fluctuations that have particularly affected the
market prices for the common stock of similarly staged companies. These broad
market fluctuations may adversely affect the market price of our common stock.
In the past, following periods of volatility in the market price of a particular
company's securities, shareholders have often brought class action securities
litigation against that company. Such litigation, if brought against us, could
result in substantial costs and a diversion of management's attention and
resources.

CERTAIN ANTI-TAKEOVER CLAUSES IN OUR CHARTER AND BY-LAW PROVISIONS AND IN
DELAWARE LAW MAY MAKE AN ACQUISITION OF US MORE DIFFICULT.

         Our Restated Certificate of Incorporation authorizes the Board of
Directors to issue, without stockholder approval, up to 1,000,000 shares of
preferred stock with voting, conversion and other rights and preferences that
could adversely affect the voting power or other rights of the holders of Common
Stock. The issuance of Preferred Stock or of rights to purchase Preferred Stock
could be used to discourage an unsolicited acquisition proposal. In addition,
the possible issuance of Preferred Stock could discourage a proxy contest, make
more difficult the acquisition of a substantial block of our Common Stock or
limit the price that investors might be willing to pay for shares of our Common
Stock. The Restated Certificate provides for staggered terms for the members of
the Board of Directors. A staggered Board of Directors and certain provisions of
our By-laws and of Delaware law applicable to us could delay or make more
difficult a merger, tender offer or proxy contest involving us. We, for example,
are subject to Section 203 of the General Corporate Law of Delaware, which,
subject to certain exceptions, restricts certain transactions and business
combinations between a corporation and a stockholder owning 15% or more of the
corporation's outstanding voting stock for a period of three years from the date
the stockholder becomes an interested stockholder. These provisions may have the
effect of delaying or preventing a change of control of us without action by the
stockholders and, therefore, could adversely affect the price of our stock.



                                   16




                  CAUTIONARY NOTE ON FORWARD-LOOKING STATEMENTS

     This prospectus and the documents incorporated by reference contain
forward-looking statements within the meaning of Section 27A of the
Securities Act and Section 21E of the Exchange Act. These statements can be
identified by the use of forward-looking terminology such as "may," "will,"
"could," "expect," "anticipate," "estimate," "continue" or other similar
words. These statements discuss future expectations, contain projections of
results of operations or of financial condition or state trends and known
uncertainties or other forward-looking information. Examples of
forward-looking statements can be found in the discussion set forth under
"Management's Discussion and Analysis of Financial Condition and Results of
Operations" and "Business" in the Form 10-K for the year ended December 31,
2001 filed with the SEC on March 29, 2002 and incorporated in this prospectus
by reference. Such statements are based on current expectations that involve
a number of uncertainties. When considering forward-looking statements, you
should keep in mind that the risk factors noted above and other factors noted
throughout this prospectus or incorporated by reference could cause our
actual results to differ significantly from those contained in any
forward-looking statement. We do not intend to update any forward-looking
statements to conform to actual results unless required by law.


                                      17





                                 USE OF PROCEEDS

     We intend to use the net proceeds from the sale of the common stock
offered by this prospectus, if any, for general corporate purposes including
research and development and for the acquisition of, or investment in,
companies, technologies or assets that complement our business. However, we
have no present understandings, commitments or agreements to enter into any
potential acquisitions or to make any investments.

     The amounts actually expended for each purpose may vary significantly
depending upon numerous factors, including the amount and timing of the
proceeds from the sale of common stock offered by this prospectus, progress
of our research, drug discovery and development programs, the results of
pre-clinical and clinical studies, the timing of regulatory approvals,
technological advances, determinations as to commercial potential of our
compounds and the status of competitive products. In addition, expenditures
will also depend upon the establishment of collaborative research
arrangements with other companies and other factors. Pending application of
the net proceeds, we intend to invest the net proceeds of the offering in
short-term, investment-grade, interest-bearing securities. Additional
information about the use of net proceeds from the sale of common stock
offered by this propsectus may be set forth in the prospectus supplement
relative to the specific offering.


                                     18




                              PLAN OF DISTRIBUTION

     We may offer the common stock:

o    directly to purchasers;

o    to or through underwriters;

o    through dealers, agents or institutional investors; or

o    through a combination of such methods.

Regardless of the method used to sell the common stock, we will provide a
prospectus supplement that will disclose:

o    the identity of any underwriters, dealers, agents or investors who purchase
     the common stock;

o    the material terms of the distribution, including the number of shares sold
     and the consideration paid;

o    any over-allotment options under which underwriters may purchase
     additional securities from us;

o    the amount of any compensation, discounts or commissions to be received by
     the underwriters, dealers or agents;

o    any public offering price;

o    the terms of any indemnification provisions, including indemnification from
     liabilities under the federal securities laws; and

o    the nature of any transaction by an underwriter, dealer or agent during the
     offering that is intended to stabilize or maintain the market price of the
     common stock.

SALE THROUGH AGENTS

     We may designate agents to solicit purchases for the period of the agent's
appointment or to sell the common stock on a continuing basis. Unless we inform
you otherwise in the applicable prospectus supplement, any agent will agree to
use its reasonable best efforts to solicit purchases for the period of the
agent's appointment.

SALE THROUGH UNDERWRITERS OR DEALERS



     If underwriters are used in an offering of the common stock, we will
execute an underwriting agreement with such underwriters and will set out the
name of each underwriter and the terms of the transaction (including any
underwriting discounts and other terms constituting compensation of the
underwriters and any dealers) in a prospectus supplement. In the event that
we use an underwriter in connection with an offering of common stock pursuant
to this registration statement, we will file a post-effective amendment to
the registration statement or a Current Report on Form 8-K in order to file
any underwriting agreement with such underwriter or underwriters.  If an
underwriting syndicate is used, the managing underwriter(s) will be set forth
on the cover of a prospectus supplement. Common stock may be acquired by the
underwriters for their own accounts and may be resold from time to time in
one or more transactions, including negotiated transactions, at a fixed
public offering price or at varying prices determined at the time of sale.
Any public offering price and any discounts or concessions allowed or
reallowed or paid to dealers may be changed from time to time. We may use
underwriters with whom we have a material relationship. We will describe in
the prospectus supplement that names the underwriter the nature of any such
relationship.



     If dealers are used in an offering of the common stock, we will sell the
common stock to the dealers as principals. The dealers then may resell such
common stock to the public at varying prices, which they determine at the time
of resale.

                                    19



COMPENSATION OF UNDERWRITERS, DEALERS AND AGENTS

     Underwriters, dealers and agents that participate in the distribution of
the common stock may be underwriters as defined in the Securities Act of 1933
and any discounts or commissions they receive from us, as well as any profit on
their resale of the common stock, may be treated as underwriting discounts and
commissions under the Securities Act. We will identify in the applicable
prospectus supplement any underwriters, dealers or agents and will describe
their compensation. We may have agreements with the underwriters, dealers or
agents to indemnify them against specified civil liabilities, including
liabilities under the Securities Act. Underwriters, dealers and agents may
engage in transactions with or perform services for us in the ordinary course of
their businesses.

DIRECT SALES

     We may sell the common stock directly. In that event, no underwriters or
agents would be involved. We may sell the common stock directly to institutional
investors or others who may be deemed to be underwriters within the meaning of
the Securities Act with respect to any sale of that common stock.

DELAYED DELIVERY CONTRACTS

     If we so indicate in a prospectus supplement, we may authorize
underwriters, dealers or agents to solicit offers from selected types of
institutions to purchase common stock from us at the public offering price under
delayed delivery requirements. These contracts would provide for payment and
delivery on a specified date in the future. Institutions with which such
contracts may be made include commercial and savings banks, insurance companies,
pension funds, investment companies, educational and charitable institutions and
others. The contracts would be subject only to those conditions described in the
prospectus supplement. The applicable prospectus supplement relating to such
contracts will set forth the price to be paid for common stock under the
contracts, the commission payable for solicitation of the contracts and the date
or dates in the future for delivery of the common stock under the contracts.

STABILIZATION ACTIVITIES



     During and after an offering through underwriters, the underwriters may
purchase and sell the common stock in the open market. These transactions may
include over-allotment and stabilizing transactions and purchases to cover
syndicate short positions created in connection with the offering. The
underwriters may also impose a penalty bid, in which selling concessions allowed
to syndicate members or other broker-dealers for the offered common stock sold
for their account may be reclaimed by the syndicate if the offered common stock
is repurchased by the syndicate in stabilizing or covering transactions. These
activities may stabilize, maintain or otherwise affect the market price of the
offered common stock, which may be higher than the price that might otherwise
prevail in the open market. If commenced, these activities may be discontinued
at any time. Such stabilization activities will only be conducted in
conjunction with a firm commitment underwritten offering.



PASSIVE MARKET MAKING

     Any underwriters who are qualified market makers on the NASDAQ National
Market may engage in passive market making transactions in the common stock on
the Nasdaq National Market in accordance with Rule 103 of Regulation M, during
the business day prior to the pricing of the offering, before the commencement
of offers or sales of the securities. Passive market makers must comply with
applicable volume and price limitations and must be identified as passive market
makers. In general, a passive market maker must display its bid at a price not
in excess of highest independent bid for the security; if all independent bids
are lowered below the passive market maker's bid, however, the passive market
maker's bid then must be lowered when certain purchase limits are exceeded.

                                     20



                                  LEGAL MATTERS

     The validity of the issuance of the common stock offered in this prospectus
is being passed upon for us by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
P.C., Boston, Massachusetts.

                                     EXPERTS

     Our financial statements, appearing in our Annual Report on Form 10-K for
the year ended December 31, 2001, have been audited by Ernst & Young LLP,
independent auditors, as set forth in their report thereon included therein and
incorporated herein by reference. Such financial statements are incorporated
herein by reference in reliance upon such report given on the authority of such
firm as experts in accounting and auditing.

                       WHERE YOU CAN FIND MORE INFORMATION

     We are a public company and file annual, quarterly and special reports,
proxy statements and other information with the Securities and Exchange
Commission. You may read and copy any document we file at the SEC's Public
Reference Room at 450 Fifth Street, N.W., Washington, D.C. 20549. You can
request copies of these documents by writing to the SEC and paying a fee for the
copying cost. Please call the SEC at 1-800-SEC-0330 for more information about
the operation of the public reference room. Our SEC filings are also available
to the public at the SEC's web site at "http://www.sec.gov." In addition, our
stock is listed for trading on the Nasdaq National Market. You can read and copy
reports and other information concerning us at the offices of the National
Association of Securities Dealers, Inc. located at 1735 K Street, Washington,
D.C. 20006.

     This prospectus is only part of a Registration Statement on Form S-3 that
we have filed with the SEC under the Securities Act of 1933 and therefore omits
certain information contained in the Registration Statement. We have also filed
exhibits and schedules with the Registration Statement that are excluded from
this prospectus, and you should refer to the applicable exhibit or schedule for
a complete description of any statement referring to any contract or other
document. You may:

         o    inspect a copy of the Registration Statement, including the
              exhibits and schedules, without charge at the public reference
              room, or

         o    obtain a copy from the SEC upon payment of the fees prescribed by
              the SEC.


                                      21



                     INCORPORATION OF DOCUMENTS BY REFERENCE

    The SEC allows us to "incorporate by reference" the information we file with
it, which means that we can disclose important information to you by referring
you to those documents. The information incorporated by reference is considered
to be a part of this prospectus and information that we file later with the SEC
will automatically update and supersede this information. We incorporate by
reference the documents listed below and any future filings made with the SEC
under Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934
until the sale of all of the shares of common stock. The documents we are
incorporating by reference are:



o    our Quarterly Reports on Form 10-Q for the quarterly periods ended
     March 31, 2002, June 30, 2002 and September 30, 2002;



o    our Annual Report on Form 10-K for the fiscal year ended
     December 31, 2001;

o    our Forms 8-K filed on November 14, 2002, March 18, 2002, January 25,
     2002, January 16, 2002 and January 14, 2002;

o    our Definitive Proxy Statement filed on April 30, 2002; and

o    the description of our common stock contained in "Description of Capital
     Stock" in the Registration Statement on Form S-1 filed with the SEC on
     January 30, 1997 (File No. 333-17581), including any amendment or report
     filed for the purpose of updating such description.

     You may request a copy of these filings at no cost by writing or
telephoning our Investor Relations Officer at the following address and phone
number:

                                        EPIX Medical, Inc.
                                        71 Rogers Street
                                        Cambridge, Massachusetts 02142
                                        (617) 250-6000

     This prospectus is part of a Registration Statement that we filed with the
SEC. You should rely only on the information incorporated by reference in or
provided in this prospectus and the Registration Statement. We have not
authorized any other person to provide you with different information. We are
not making an offer of these securities in any state where the offer is not
permitted. You should not assume that the information in this prospectus is
accurate as of any date other than the date on the front of this document.

                                      22



                 PART II. INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 14.  OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION

     The table sets forth our estimates of our expenses in connection with the
issuance and distribution of the common stock being registered.



ITEM                                                   AMOUNT
                                                       ------

SEC registration fee..............................   $  5,999.00
Legal fees and expenses...........................   $ 75,000.00
Accounting fees and expenses......................   $ 75,000.00
Miscellaneous fees and expenses...................   $ 10,000.00
                                                     -----------
Total.............................................   $165,999.00
                                                     ===========



ITEM 15.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.

     Section 145(a) of the General Corporation Law of the State of Delaware
provides that a Delaware corporation may indemnify any person who was or is a
party or is threatened to be made a party to any threatened, pending or
completed action, suit or proceeding, whether civil, criminal, administrative or
investigative (other than an action by or in the right of the corporation) by
reason of the fact that he is or was a director, officer, employee or agent of
the corporation or is or was serving at the request of the corporation as a
director, officer, employee or agent of another corporation or enterprise,
against expenses, judgments, fines and amounts paid in settlement actually and
reasonably incurred by him in connection with such action, suit or proceeding if
he acted in good faith and in a manner he reasonably believed to be in or not
opposed to the best interests of the corporation, and, with respect to any
criminal action or proceeding, had no cause to believe his conduct was unlawful.

     Section 145(b) provides that a Delaware corporation may indemnify any
person who was or is a party or is threatened to be made a party to any
threatened, pending or completed action or suit by or in the right of the
corporation to procure a judgment in its favor by reason of the fact that such
person acted in any of the capacities set forth above, against expenses actually
and reasonably incurred by him in connection with the defense or settlement of
such action or suit if he acted under similar standards, except that no
indemnification may be made in respect of any claim, issue or matter as to which
such person shall have been adjudged to be liable to the corporation unless and
only to the extent that the court in which such action or suit was brought shall
determine that despite the adjudication of liability, such person is fairly and
reasonably entitled to be indemnified for such expenses which the court shall
deem proper.

     Section 145 further provides that to the extent a director or officer of a
corporation has been successful in the defense of any action, suit or proceeding
referred to in subsections (a) and (b) or in the defense of any claim, issue or
matter therein, he shall be indemnified against expenses actually and reasonably
incurred by him in connection therewith; that indemnification provided for by
Section 145 shall not be deemed exclusive of any other rights to which the
indemnified party may be entitled; and that the corporation may purchase and
maintain insurance on behalf of a director or officer of the corporation against
any liability asserted against him or incurred by him in any such capacity or
arising out of his status as such whether or not the corporation would have the
power to indemnify him against such liabilities under such Section 145.

     The Certificate of Incorporation, as amended, and By-laws, as amended, of
the Company provide for indemnification of the Company's directors and officers
to the fullest extent permitted by law. The By-laws also permit the Board of
Directors to authorize the Company to purchase and maintain insurance against
any liability asserted against any director, officer, employee or agent of the
Company arising out of his capacity as such. Insofar as indemnification for
liabilities under the Securities Act may be permitted to directors, officers, or
controlling persons of the Company pursuant to the Company's Certificate of
Incorporation, as amended, its By-laws, as amended, and the Delaware General
Corporation Law, the Company has been informed that in the opinion of the
Commission such indemnification is against public policy as expressed in such
Act and is therefore unenforceable.

     As permitted by Section 102(b)(7) of the Delaware General Corporation Law,
the Company's Certificate of Incorporation, as amended, provides that directors
of the Company shall not be personally liable to the Company or its stockholders
for monetary damages for breach of fiduciary duty as a director, except for
liability (i) for any breach of the director's duty of loyalty to the Company or
its stockholders, (ii) for acts or omissions not in good faith or which involve
intentional misconduct or a knowing violation of law, (iii) under Section 174 of
the Delaware General Corporation Law, relating to prohibited dividends or
distributions or the repurchase or redemption of stock or (iv) for any
transaction from which the director derives an improper personal benefit. As a
result of this provision, the Company and its stockholders may be unable to
obtain monetary damages from a director for breach of his or her duty of care.


                                      II-1



ITEM 16.  EXHIBITS

EXHIBIT
NUMBER                  DESCRIPTION
                        -----------

4.1**    Restated Certificate of Incorporation of the Company. (Filed as Exhibit
         4.1 to the Company's Registration Statement on Form S-8 (File No.
         333-30531) and incorporated herein by reference.)

4.2**    Amended and Restated By-laws of the Company. (Filed as Exhibit 4.2 to
         the Company's Registration Statement on Form S-8 (File No. 333-30531)
         and incorporated herein by reference.)

4.3**    Specimen certificate for shares of Common Stock of the Company. (Filed
         as Exhibit 4.1 to the Company's Registration Statement on Form S-1
         (File No. 333-17581) and incorporated herein by reference.)

5.1**    Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., with
         respect to the legality of the securities being registered.

23.1     Consent of Ernst & Young LLP.

23.2**   Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
         (included in Exhibit 5.1).

24.1**   Power of Attorney (included on signature page).

-------------------

** Previously filed


ITEM 17.  UNDERTAKINGS.

         (a) The undersigned Registrant hereby undertakes:

         (1) To file, during any period in which offers or sales are being made,
         a post-effective amendment to this Registration Statement:

         (i) To include any prospectus required by Section 10(a)(3) of the
         Securities Act of 1933;

         (ii) To reflect in the prospectus any facts or events arising after the
         effective date of the registration statement (or the most recent
         post-effective amendment thereof) which, individually or in the
         aggregate, represent a fundamental change in the information set forth
         in the registration statement. Notwithstanding the foregoing, any
         increase or any decrease in volume of securities offered (if the total
         dollar value of securities offered would not exceed that which was
         registered) and any deviation from the low or high end of the estimated
         maximum offering range may be reflected in the form of prospectus filed
         with the Commission pursuant to Rule 424(b) if, in the aggregate, the
         changes in volume and price represent no more than a 20% change in the
         maximum aggregate offering price set forth in the "Calculation of
         Registration Fee" table in the effective registration statement; and

         (iii) To include any material information with respect to the plan of
         distribution not previously disclosed in the registration statement or
         any material change to such information in the registration statement;

         provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not
         apply if the registration statement is on Form S-3, Form S-8 or Form
         F-3, and the information required to be included in a post-effective
         amendment by those paragraphs is contained in periodic reports filed
         with or furnished to the Commission by the Registrant pursuant to
         Section 13 or Section 15(d) of the Securities Exchange Act of 1934 that
         are incorporated by reference in the registration statement.

         (2) That, for the purpose of determining any liability under the
         Securities Act of 1933, each such post-effective amendment shall be
         deemed to be a new registration statement relating to the securities
         offered therein, and the offering of such securities at that time shall
         be deemed to be the initial bona fide offering thereof.

         (3) To remove from registration by means of a post-effective amendment
         any of the securities being registered which remain unsold at the
         termination of the offering.


                                      II-2




         (b) Insofar as indemnification for liabilities arising under the
         Securities Act of 1933 may be permitted to directors, officers and
         controlling persons of the Registrant, the Registrant has been advised
         that in the opinion of the Securities and Exchange Commission such
         indemnification is against public policy as expressed in the Act and
         is, therefore, unenforceable. In the event that a claim for
         indemnification against such liabilities (other than the payment by the
         Registrant of expenses incurred or paid by a director, officer or
         controlling person of the Registrant in the successful defense of any
         action, suit or proceeding) is asserted by such director, officer or
         controlling person in connection with the securities being registered,
         the Registrant will, unless in the opinion of its counsel the matter
         has been settled by controlling precedent, submit to a court of
         appropriate jurisdiction the question whether such indemnification by
         it is against public policy as expressed in the Act and will be
         governed by the final adjudication of such issue.

         (c) The undersigned Registrant hereby undertakes that, for purposes of
         determining any liability under the Securities Act of 1933, each filing
         of the Registrant's annual report pursuant to Section 13(a) or Section
         15(d) of the Securities Exchange Act of 1934 that is incorporated by
         reference in the registration statement shall be deemed to be a new
         registration statement relating to the securities offered therein, and
         the offering of such securities at that time shall be deemed to be the
         initial bona fide offering thereof.

         (d) The undersigned registrant hereby undertakes to deliver or cause to
         be delivered with the prospectus, to each person to whom the prospectus
         is sent or given, the latest annual report to security holders that is
         incorporated by reference in the prospectus and furnished pursuant to
         and meeting the requirements of Rule 14a-3 or Rule 14c-3 under the
         Securities Exchange Act of 1934; and, where interim financial
         information required to be presented by Article 3 of Regulation S-X are
         not set forth in the prospectus, to deliver, or cause to be delivered
         to each person to whom the prospectus is sent or given, the latest
         quarterly report that is specifically incorporated by reference in the
         prospectus to provide such interim financial information.


                                      II-3




                                   SIGNATURES


     Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it
meets all the requirements for filing on Form S-3 and has duly caused this
Amendment No. 3 to Form S-3 Registration Statement to be signed on its behalf
by the undersigned, thereunto duly authorized, in Cambridge, Massachusetts on
December 20, 2002.


                                                  EPIX MEDICAL, INC.

                                                  BY: /s/ MICHAEL D. WEBB
                                                  ----------------------------
                                                  Michael D. Webb
                                                  Chief Executive Officer



Pursuant to the requirements of the Securities Act of 1933, as amended, this
Amendment No. 3 to Registration Statement on Form S-3 has been signed below by
the following persons in the capacities and on the dates indicated.







   SIGNATURE                                   TITLE                                       DATE
   ---------                                   -----                                       ----
                                                                                    
                                            Chief Executive Officer                       December 20, 2002
/s/ MICHAEL D. WEBB                         (Principal Executive Officer)
-----------------------------------
Michael D. Webb

                                            Senior Vice President of Finance and          December 20, 2002
/s/ PEYTON J. MARSHALL                      Administration and Chief Financial Officer
-----------------------------------         (Principal Financial and Accounting Officer)
Peyton J. Marshall


                  *                          Chairman of the Board and Director           December 20, 2002
-----------------------------------
Christopher F. O. Gabrieli


                  *                          Director                                     December 20, 2002
-----------------------------------
Stanley T. Crooke, M.D., Ph.D.


                  *                          Director                                     December 20, 2002
-----------------------------------
Peter Wirth


                  *                          Director                                     December 20, 2002
-----------------------------------
Randall B. Lauffer, Ph.D.


*By: /s/ Michael D. Webb
-----------------------------------
Michael D. Webb
Attorney-in-fact






                          INDEX TO EXHIBITS FILED WITH
                         FORM S-3 REGISTRATION STATEMENT

EXHIBIT
NUMBER                     DESCRIPTION
-------                    -----------

4.1**    Restated Certificate of Incorporation of the Company. (Filed as Exhibit
         4.1 to the Company's Registration Statement on Form S-8 (File No.
         333-30531) and incorporated herein by reference.)

4.2**    Amended and Restated By-laws of the Company. (Filed as Exhibit 4.2 to
         the Company's Registration Statement on Form S-8 (File No. 333-30531)
         and incorporated herein by reference.)

4.3**    Specimen certificate for shares of Common Stock of the Company. (Filed
         as Exhibit 4.1 to the Company's Registration Statement on Form S-1
         (File No. 333-17581) and incorporated herein by reference.)

5.1**    Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., with
         respect to the legality of the securities being registered.

23.1     Consent of Ernst & Young LLP.

23.2**   Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
         (included in Exhibit 5.1).

24.1**   Power of Attorney (included on signature page).

-------------------
** Previously filed