PAGE 1 000 B000000 10/31/2010 000 C000000 0001227073 000 D000000 N 000 E000000 NF 000 F000000 Y 000 G000000 N 000 H000000 N 000 I000000 6.1 000 J000000 A 001 A000000 WFA MULTI-SECTOR INCOME FUND 001 B000000 811-21331 001 C000000 4153960446 002 A000000 525 MARKET STREET 002 B000000 SAN FRANCISCO 002 C000000 CA 002 D010000 94105 003 000000 N 004 000000 N 005 000000 N 006 000000 N 007 A000000 N 007 B000000 0 007 C010100 1 008 A000001 WELLS FARGO FUNDS MANAGEMENT, LLC 008 B000001 A 008 C000001 801-58237 008 D010001 SAN FRANCISCO 008 D020001 CA 008 D030001 94105 008 A000002 WELLS CAPITAL MANAGEMENT, INC. 008 B000002 S 008 C000002 801-21122 008 D010002 SAN FRANCISCO 008 D020002 CA 008 D030002 94105 008 A000003 First International Advisors, LLC 008 B000003 S 008 C000003 801-00000 008 D010003 London 008 D050003 United Kingdom 010 A000001 WELLS FARGO FUNDS MANAGEMENT, LLC 010 B000001 801-58237 010 C010001 SAN FRANCISCO 010 C020001 CA 010 C030001 94105 011 A000001 Wells Fargo Funds Distributor, LLC 011 B000001 8-066716 011 C010001 San Francisco 011 C020001 CA 011 C030001 94105 012 A000001 Computershare Trust Company, N.A PAGE 2 012 B000001 85-000 012 C010001 Providence 012 C020001 RI 012 C030001 02940 012 C040001 3010 013 A000001 KPMG LLP 013 B010001 Boston 013 B020001 MA 013 B030001 02110 014 A000001 HD VEST INVESTMENT SERVICES, INC. 014 B000001 8-029892 014 A000002 Wells Fargo Brokerage Services, LLC 014 B000002 8-033283 014 A000003 Wells Fargo Institutional Securities, LLC 014 B000003 8-016600 014 A000004 Wells Fargo Investments, LLC 014 B000004 8-0158211 014 A000005 Wells Fargo Securities, LLC 014 B000005 8-0142443 014 A000006 Wells Fargo Funds Distributor, LLC 014 B000006 8-066716 015 A000001 STATE STREET BANK AND TRUST COMPANY 015 B000001 C 015 C010001 KANSAS CITY 015 C020001 MO 015 C030001 64105 015 E010001 X 018 000000 Y 019 A000000 Y 019 B000000 152 019 C000000 WELLSFARGO 020 A000001 National Financial Services Corp. 020 B000001 04-3523567 020 C000001 2 020 A000002 UBS SECURITIES (FORMERLY UBS WARBURG) 020 B000002 13-3873456 020 C000002 1 020 A000003 JEFFERIES & CO. INC. 020 B000003 95-2622900 020 C000003 1 020 A000004 Pershing LLC 020 B000004 13-2741729 020 C000004 1 020 A000005 Cantor Fitzgerald and Co. 020 C000005 1 021 000000 6 022 A000001 BARCLAYS CAPITAL INC 022 B000001 06-1031656 022 C000001 93735 022 D000001 48764 022 A000002 JP MORGAN SECURITIES PAGE 3 022 B000002 13-3224016 022 C000002 63372 022 D000002 52159 022 A000003 BANK OF AMERICA SECURITIES 022 B000003 56-2058405 022 C000003 61414 022 D000003 44215 022 A000004 CITIGROUP 022 B000004 52-1568099 022 C000004 42365 022 D000004 30631 022 A000005 GOLDMAN SACHS & CO 022 B000005 13-5108880 022 C000005 37260 022 D000005 35489 022 A000006 Morgan Stanley & Co. Inc 022 B000006 13-2655998 022 C000006 33454 022 D000006 35670 022 A000007 DEUTSCHE BANK ALEX BROWN 022 B000007 13-2730828 022 C000007 27470 022 D000007 37619 022 A000008 Pershing LLC 022 B000008 13-2741729 022 C000008 18408 022 D000008 44791 022 A000009 Credit Suisse Securities 022 B000009 13-5659485 022 C000009 30324 022 D000009 26517 022 A000010 RBS SECURITIES, INC. 022 B000010 13-3172275 022 C000010 22214 022 D000010 25637 023 C000000 658410 023 D000000 575904 024 000000 Y 025 A000001 MORGAN STANLEY 025 B000001 13-2655998 025 C000001 D 025 D000001 949 026 A000000 N 026 B000000 Y 026 C000000 N 026 D000000 Y 026 E000000 N 026 F000000 N 026 G010000 N 026 G020000 Y 026 H000000 N PAGE 4 027 000000 N 028 A010000 0 028 A020000 0 028 A030000 0 028 A040000 0 028 B010000 0 028 B020000 0 028 B030000 0 028 B040000 0 028 C010000 0 028 C020000 0 028 C030000 0 028 C040000 0 028 D010000 0 028 D020000 0 028 D030000 0 028 D040000 0 028 E010000 0 028 E020000 0 028 E030000 0 028 E040000 0 028 F010000 0 028 F020000 0 028 F030000 0 028 F040000 0 028 G010000 0 028 G020000 0 028 G030000 0 028 G040000 0 028 H000000 0 030 A000000 0 030 B000000 0.00 030 C000000 0.00 031 A000000 0 031 B000000 0 032 000000 0 033 000000 0 035 000000 0 036 B000000 0 038 000000 0 042 A000000 0 042 B000000 0 042 C000000 0 042 D000000 0 042 E000000 0 042 F000000 0 042 G000000 0 042 H000000 0 043 000000 0 044 000000 0 045 000000 Y PAGE 5 046 000000 N 047 000000 Y 048 000000 0.740 048 A010000 0 048 A020000 0.000 048 B010000 0 048 B020000 0.000 048 C010000 0 048 C020000 0.000 048 D010000 0 048 D020000 0.000 048 E010000 0 048 E020000 0.000 048 F010000 0 048 F020000 0.000 048 G010000 0 048 G020000 0.000 048 H010000 0 048 H020000 0.000 048 I010000 0 048 I020000 0.000 048 J010000 0 048 J020000 0.000 048 K010000 0 048 K020000 0.000 049 000000 N 050 000000 N 051 000000 N 052 000000 N 053 A000000 Y 053 B000000 Y 053 C000000 N 054 A000000 Y 054 B000000 N 054 C000000 N 054 D000000 N 054 E000000 N 054 F000000 N 054 G000000 N 054 H000000 N 054 I000000 N 054 J000000 Y 054 K000000 N 054 L000000 N 054 M000000 Y 054 N000000 N 054 O000000 N 055 A000000 N 055 B000000 Y 056 000000 Y 057 000000 N PAGE 6 058 A000000 N 059 000000 Y 060 A000000 Y 060 B000000 Y 061 000000 0 062 A000000 Y 062 B000000 0.0 062 C000000 0.0 062 D000000 0.0 062 E000000 0.0 062 F000000 0.0 062 G000000 0.0 062 H000000 0.0 062 I000000 0.0 062 J000000 0.0 062 K000000 0.0 062 L000000 3.0 062 M000000 0.0 062 N000000 30.6 062 O000000 0.0 062 P000000 78.1 062 Q000000 20.1 062 R000000 -31.8 063 A000000 0 063 B000000 9.3 064 A000000 N 064 B000000 Y 065 000000 N 066 A000000 N 067 000000 N 068 A000000 N 068 B000000 N 069 000000 N 070 A010000 Y 070 A020000 Y 070 B010000 Y 070 B020000 N 070 C010000 Y 070 C020000 N 070 D010000 Y 070 D020000 N 070 E010000 Y 070 E020000 Y 070 F010000 Y 070 F020000 N 070 G010000 Y 070 G020000 N 070 H010000 Y 070 H020000 N 070 I010000 N 070 I020000 N PAGE 7 070 J010000 Y 070 J020000 Y 070 K010000 Y 070 K020000 Y 070 L010000 Y 070 L020000 Y 070 M010000 Y 070 M020000 Y 070 N010000 Y 070 N020000 Y 070 O010000 Y 070 O020000 Y 070 P010000 N 070 P020000 N 070 Q010000 Y 070 Q020000 N 070 R010000 Y 070 R020000 N 071 A000000 690780 071 B000000 601315 071 C000000 864106 071 D000000 70 072 A000000 12 072 B000000 58251 072 C000000 350 072 D000000 0 072 E000000 0 072 F000000 4920 072 G000000 447 072 H000000 0 072 I000000 31 072 J000000 278 072 K000000 0 072 L000000 142 072 M000000 24 072 N000000 0 072 O000000 0 072 P000000 513 072 Q000000 0 072 R000000 107 072 S000000 0 072 T000000 0 072 U000000 0 072 V000000 0 072 W000000 4029 072 X000000 10491 072 Y000000 2677 072 Z000000 50787 072AA000000 31616 072BB000000 0 072CC010000 17614 PAGE 8 072CC020000 0 072DD010000 54655 072DD020000 0 072EE000000 0 073 A010000 1.2996 073 A020000 0.0000 073 B000000 0.0000 073 C000000 0.0000 074 A000000 1752 074 B000000 0 074 C000000 0 074 D000000 900958 074 E000000 0 074 F000000 0 074 G000000 0 074 H000000 0 074 I000000 22755 074 J000000 13990 074 K000000 0 074 L000000 17403 074 M000000 9 074 N000000 956867 074 O000000 18450 074 P000000 503 074 Q000000 0 074 R010000 0 074 R020000 0 074 R030000 0 074 R040000 0 074 S000000 236804 074 T000000 701110 074 U010000 42055 074 U020000 0 074 V010000 16.67 074 V020000 0.00 074 W000000 0.0000 074 X000000 0 074 Y000000 0 075 A000000 0 075 B000000 665256 076 000000 16.18 077 A000000 Y 077 B000000 Y 077 C000000 Y 077 O000000 N 077 Q030000 N 078 000000 N 080 A000000 ICI Mutual Insurance Company 080 C000000 50000 081 A000000 Y 081 B000000 152 PAGE 9 082 A000000 Y 082 B000000 150 083 A000000 N 083 B000000 0 084 A000000 N 084 B000000 0 085 A000000 Y 085 B000000 N 086 A010000 0 086 A020000 0 086 B010000 0 086 B020000 0 086 C010000 0 086 C020000 0 086 D010000 0 086 D020000 0 086 E010000 0 086 E020000 0 086 F010000 0 086 F020000 0 087 A010000 WFA Multi-Sector Income Fund 087 A020000 30024Y104 087 A030000 ERC 088 A000000 N 088 B000000 N 088 C000000 N 088 D000000 N SIGNATURE KASEY PHILLIPS TITLE TREASURER