PAGE  1
000 B000000 10/31/2010
000 C000000 0001227073
000 D000000 N
000 E000000 NF
000 F000000 Y
000 G000000 N
000 H000000 N
000 I000000 6.1
000 J000000 A
001 A000000 WFA MULTI-SECTOR INCOME FUND
001 B000000 811-21331
001 C000000 4153960446
002 A000000 525 MARKET STREET
002 B000000 SAN FRANCISCO
002 C000000 CA
002 D010000 94105
003  000000 N
004  000000 N
005  000000 N
006  000000 N
007 A000000 N
007 B000000  0
007 C010100  1
008 A000001 WELLS FARGO FUNDS MANAGEMENT, LLC
008 B000001 A
008 C000001 801-58237
008 D010001 SAN FRANCISCO
008 D020001 CA
008 D030001 94105
008 A000002 WELLS CAPITAL MANAGEMENT, INC.
008 B000002 S
008 C000002 801-21122
008 D010002 SAN FRANCISCO
008 D020002 CA
008 D030002 94105
008 A000003 First International Advisors, LLC
008 B000003 S
008 C000003 801-00000
008 D010003 London
008 D050003 United Kingdom
010 A000001 WELLS FARGO FUNDS MANAGEMENT, LLC
010 B000001 801-58237
010 C010001 SAN FRANCISCO
010 C020001 CA
010 C030001 94105
011 A000001 Wells Fargo Funds Distributor, LLC
011 B000001 8-066716
011 C010001 San Francisco
011 C020001 CA
011 C030001 94105
012 A000001 Computershare Trust Company, N.A
      PAGE  2
012 B000001 85-000
012 C010001 Providence
012 C020001 RI
012 C030001 02940
012 C040001 3010
013 A000001 KPMG LLP
013 B010001 Boston
013 B020001 MA
013 B030001 02110
014 A000001 HD VEST INVESTMENT SERVICES, INC.
014 B000001 8-029892
014 A000002 Wells Fargo Brokerage Services, LLC
014 B000002 8-033283
014 A000003 Wells Fargo Institutional Securities, LLC
014 B000003 8-016600
014 A000004 Wells Fargo Investments, LLC
014 B000004 8-0158211
014 A000005 Wells Fargo Securities, LLC
014 B000005 8-0142443
014 A000006 Wells Fargo Funds Distributor, LLC
014 B000006 8-066716
015 A000001 STATE STREET BANK AND TRUST COMPANY
015 B000001 C
015 C010001 KANSAS CITY
015 C020001 MO
015 C030001 64105
015 E010001 X
018  000000 Y
019 A000000 Y
019 B000000  152
019 C000000 WELLSFARGO
020 A000001 National Financial Services Corp.
020 B000001 04-3523567
020 C000001      2
020 A000002 UBS SECURITIES (FORMERLY UBS WARBURG)
020 B000002 13-3873456
020 C000002      1
020 A000003 JEFFERIES & CO. INC.
020 B000003 95-2622900
020 C000003      1
020 A000004 Pershing LLC
020 B000004 13-2741729
020 C000004      1
020 A000005 Cantor Fitzgerald and Co.
020 C000005      1
021  000000        6
022 A000001 BARCLAYS CAPITAL INC
022 B000001 06-1031656
022 C000001     93735
022 D000001     48764
022 A000002 JP MORGAN SECURITIES
      PAGE  3
022 B000002 13-3224016
022 C000002     63372
022 D000002     52159
022 A000003 BANK OF AMERICA SECURITIES
022 B000003 56-2058405
022 C000003     61414
022 D000003     44215
022 A000004 CITIGROUP
022 B000004 52-1568099
022 C000004     42365
022 D000004     30631
022 A000005 GOLDMAN SACHS & CO
022 B000005 13-5108880
022 C000005     37260
022 D000005     35489
022 A000006 Morgan Stanley & Co. Inc
022 B000006 13-2655998
022 C000006     33454
022 D000006     35670
022 A000007 DEUTSCHE BANK ALEX BROWN
022 B000007 13-2730828
022 C000007     27470
022 D000007     37619
022 A000008 Pershing LLC
022 B000008 13-2741729
022 C000008     18408
022 D000008     44791
022 A000009 Credit Suisse Securities
022 B000009 13-5659485
022 C000009     30324
022 D000009     26517
022 A000010 RBS SECURITIES, INC.
022 B000010 13-3172275
022 C000010     22214
022 D000010     25637
023 C000000     658410
023 D000000     575904
024  000000 Y
025 A000001 MORGAN STANLEY
025 B000001 13-2655998
025 C000001 D
025 D000001     949
026 A000000 N
026 B000000 Y
026 C000000 N
026 D000000 Y
026 E000000 N
026 F000000 N
026 G010000 N
026 G020000 Y
026 H000000 N
      PAGE  4
027  000000 N
028 A010000         0
028 A020000         0
028 A030000         0
028 A040000         0
028 B010000         0
028 B020000         0
028 B030000         0
028 B040000         0
028 C010000         0
028 C020000         0
028 C030000         0
028 C040000         0
028 D010000         0
028 D020000         0
028 D030000         0
028 D040000         0
028 E010000         0
028 E020000         0
028 E030000         0
028 E040000         0
028 F010000         0
028 F020000         0
028 F030000         0
028 F040000         0
028 G010000         0
028 G020000         0
028 G030000         0
028 G040000         0
028 H000000         0
030 A000000      0
030 B000000  0.00
030 C000000  0.00
031 A000000      0
031 B000000      0
032  000000      0
033  000000      0
035  000000      0
036 B000000      0
038  000000      0
042 A000000   0
042 B000000   0
042 C000000   0
042 D000000   0
042 E000000   0
042 F000000   0
042 G000000   0
042 H000000   0
043  000000      0
044  000000      0
045  000000 Y
      PAGE  5
046  000000 N
047  000000 Y
048  000000  0.740
048 A010000        0
048 A020000 0.000
048 B010000        0
048 B020000 0.000
048 C010000        0
048 C020000 0.000
048 D010000        0
048 D020000 0.000
048 E010000        0
048 E020000 0.000
048 F010000        0
048 F020000 0.000
048 G010000        0
048 G020000 0.000
048 H010000        0
048 H020000 0.000
048 I010000        0
048 I020000 0.000
048 J010000        0
048 J020000 0.000
048 K010000        0
048 K020000 0.000
049  000000 N
050  000000 N
051  000000 N
052  000000 N
053 A000000 Y
053 B000000 Y
053 C000000 N
054 A000000 Y
054 B000000 N
054 C000000 N
054 D000000 N
054 E000000 N
054 F000000 N
054 G000000 N
054 H000000 N
054 I000000 N
054 J000000 Y
054 K000000 N
054 L000000 N
054 M000000 Y
054 N000000 N
054 O000000 N
055 A000000 N
055 B000000 Y
056  000000 Y
057  000000 N
      PAGE  6
058 A000000 N
059  000000 Y
060 A000000 Y
060 B000000 Y
061  000000        0
062 A000000 Y
062 B000000   0.0
062 C000000   0.0
062 D000000   0.0
062 E000000   0.0
062 F000000   0.0
062 G000000   0.0
062 H000000   0.0
062 I000000   0.0
062 J000000   0.0
062 K000000   0.0
062 L000000   3.0
062 M000000   0.0
062 N000000  30.6
062 O000000   0.0
062 P000000  78.1
062 Q000000  20.1
062 R000000 -31.8
063 A000000   0
063 B000000  9.3
064 A000000 N
064 B000000 Y
065  000000 N
066 A000000 N
067  000000 N
068 A000000 N
068 B000000 N
069  000000 N
070 A010000 Y
070 A020000 Y
070 B010000 Y
070 B020000 N
070 C010000 Y
070 C020000 N
070 D010000 Y
070 D020000 N
070 E010000 Y
070 E020000 Y
070 F010000 Y
070 F020000 N
070 G010000 Y
070 G020000 N
070 H010000 Y
070 H020000 N
070 I010000 N
070 I020000 N
      PAGE  7
070 J010000 Y
070 J020000 Y
070 K010000 Y
070 K020000 Y
070 L010000 Y
070 L020000 Y
070 M010000 Y
070 M020000 Y
070 N010000 Y
070 N020000 Y
070 O010000 Y
070 O020000 Y
070 P010000 N
070 P020000 N
070 Q010000 Y
070 Q020000 N
070 R010000 Y
070 R020000 N
071 A000000    690780
071 B000000    601315
071 C000000    864106
071 D000000   70
072 A000000 12
072 B000000    58251
072 C000000      350
072 D000000        0
072 E000000        0
072 F000000     4920
072 G000000      447
072 H000000        0
072 I000000       31
072 J000000      278
072 K000000        0
072 L000000      142
072 M000000       24
072 N000000        0
072 O000000        0
072 P000000      513
072 Q000000        0
072 R000000      107
072 S000000        0
072 T000000        0
072 U000000        0
072 V000000        0
072 W000000     4029
072 X000000    10491
072 Y000000     2677
072 Z000000    50787
072AA000000    31616
072BB000000        0
072CC010000    17614
      PAGE  8
072CC020000        0
072DD010000    54655
072DD020000        0
072EE000000        0
073 A010000   1.2996
073 A020000   0.0000
073 B000000   0.0000
073 C000000   0.0000
074 A000000     1752
074 B000000        0
074 C000000        0
074 D000000   900958
074 E000000        0
074 F000000        0
074 G000000        0
074 H000000        0
074 I000000    22755
074 J000000    13990
074 K000000        0
074 L000000    17403
074 M000000        9
074 N000000   956867
074 O000000    18450
074 P000000      503
074 Q000000        0
074 R010000        0
074 R020000        0
074 R030000        0
074 R040000        0
074 S000000   236804
074 T000000   701110
074 U010000    42055
074 U020000        0
074 V010000    16.67
074 V020000     0.00
074 W000000   0.0000
074 X000000        0
074 Y000000        0
075 A000000        0
075 B000000   665256
076  000000    16.18
077 A000000 Y
077 B000000 Y
077 C000000 Y
077 O000000 N
077 Q030000 N
078  000000 N
080 A000000 ICI Mutual Insurance Company
080 C000000    50000
081 A000000 Y
081 B000000 152
      PAGE  9
082 A000000 Y
082 B000000      150
083 A000000 N
083 B000000        0
084 A000000 N
084 B000000        0
085 A000000 Y
085 B000000 N
086 A010000      0
086 A020000      0
086 B010000      0
086 B020000      0
086 C010000      0
086 C020000      0
086 D010000      0
086 D020000      0
086 E010000      0
086 E020000      0
086 F010000      0
086 F020000      0
087 A010000 WFA Multi-Sector Income Fund
087 A020000 30024Y104
087 A030000 ERC
088 A000000 N
088 B000000 N
088 C000000 N
088 D000000 N
SIGNATURE   KASEY PHILLIPS
TITLE       TREASURER