Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
RA CAPITAL MANAGEMENT, LLC
  2. Issuer Name and Ticker or Trading Symbol
CURIS INC [CRIS]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
C/O RA CAPITAL MANAGEMENT, LLC, 111 HUNTINGTON AVE., SUITE 610
3. Date of Earliest Transaction (Month/Day/Year)
04/15/2008
(Street)

BOSTON, MA 02199
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 04/15/2008   S   1,300,000 (1) D $ 1.4 6,250,564 I See Footnote (2)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
RA CAPITAL MANAGEMENT, LLC
C/O RA CAPITAL MANAGEMENT, LLC
111 HUNTINGTON AVE., SUITE 610
BOSTON, MA 02199
    X    
RA Capital Biotech Fund LP
C/O RA CAPITAL MANAGEMENT, LLC
111 HUNTINGTON AVE., SUITE 610
BOSTON, MA 02199
    X    
RA Capital Biotech Fund II, L.P.
C/O RA CAPITAL MANAGEMENT, LLC
111 HUNTINGTON AVE., SUITE 610
BOSTON, MA 02199
    X    
ALDRICH RICHARD
C/O RA CAPITAL MANAGEMENT, LLC
111 HUNTINGTON AVE., SUITE 610
BOSTON, MA 02199
    X    
Kolchinsky Peter
C/O RA CAPITAL MANAGEMENT, LLC
111 HUNTINGTON AVE., SUITE 610
BOSTON, MA 02199
    X    

Signatures

 Peter Kolchinsky, Manager of RA Capital Management, LLC   04/17/2008
**Signature of Reporting Person Date

 Peter Kolchinsky, Manager of RA Capital Management, LLC, the General Partner of RA Capital Biotech Fund, L.P.   04/17/2008
**Signature of Reporting Person Date

 Peter Kolchinsky, Manager of RA Capital Management, LLC, the General Partner of RA Capital Biotech Fund II, L.P.   04/17/2008
**Signature of Reporting Person Date

 Richard Aldrich   04/17/2008
**Signature of Reporting Person Date

 Peter Kolchinsky   04/17/2008
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The disposed shares represent 1,286,350 shares sold by RA Capital Biotech Fund, L.P. ("Fund I") and 13,650 shares sold by RA Capital Biotech Fund II, L.P. ("Fund II").
(2) RA Capital Management, LLC (the "General Partner") is the general partner of both Fund I and Fund II, and Richard H. Aldrich and Peter Kolchinsky are the sole managers of the General Partner. Each of the Reporting Persons disclaims his or its beneficial ownership of any shares of the above named Issuer reported herein, except to the extent of his or its pecuniary interest therein.

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