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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                 SCHEDULE 13G/A

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934

                               (AMENDMENT NO. 2)*




                                  NOVAMED, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)


                                  COMMON STOCK
--------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                    66986W108
--------------------------------------------------------------------------------
                                 (CUSIP Number)


                                DECEMBER 31, 2008
--------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

[ ]   Rule 13d-1(b)

[X]   Rule 13d-1(c)

[ ]   Rule 13d-1(d)

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).



PERSONS WHO RESPOND TO THE COLLECTION OF INFORMATION  CONTAINED IN THIS FORM ARE
NOT REQUIRED TO RESPOND  UNLESS THE FORM DISPLAYS A CURRENTLY  VALID OMB CONTROL
NUMBER.




--------------------                                         -------------------
CUSIP No.  66986W108                   13G/A                 Page 2 of 9 Pages
--------------------                                         -------------------


    1.      NAMES OF REPORTING PERSONS

            Great Point Partners, LLC

            I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):

            37-1475292

    2.      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

            (a)   [ ]

            (b)   [ ]

--------------------------------------------------------------------------------
    3.      SEC USE ONLY


--------------------------------------------------------------------------------

    4.      CITIZENSHIP OR PLACE OF ORGANIZATION

            USA

NUMBER OF SHARES          5.    SOLE VOTING POWER
 BENEFICIALLY
 OWNED BY EACH                                                         0
REPORTING PERSON
      WITH                6.    SHARED VOTING POWER

                                                                    904,908

                          7.    SOLE DISPOSITIVE POWER

                                                                       0

                          8.    SHARED DISPOSITIVE POWER

                                                                    904,908

    9.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                             904,908

   10.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
            (See Instructions)
                                                                             [ ]

   11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                     3.83%

   12.      TYPE OF REPORTING PERSON (See Instructions)

                     OO




--------------------                                         -------------------
CUSIP No.  66986W108                   13G/A                 Page 3 of 9 Pages
--------------------                                         -------------------

    1.      NAMES OF REPORTING PERSONS

            Dr. Jeffrey R. Jay, M.D.

            I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):

    2.      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

            (a)   [ ]

            (b)   [ ]

--------------------------------------------------------------------------------
    3.      SEC USE ONLY


--------------------------------------------------------------------------------

    4.      CITIZENSHIP OR PLACE OF ORGANIZATION

            USA

NUMBER OF SHARES          5.    SOLE VOTING POWER
 BENEFICIALLY
 OWNED BY EACH                                                         0
REPORTING PERSON
      WITH                6.    SHARED VOTING POWER

                                                                    904,908

                          7.    SOLE DISPOSITIVE POWER

                                                                       0

                          8.    SHARED DISPOSITIVE POWER

                                                                    904,908

    9.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                          904,908

   10.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
            (See Instructions)
                                                                             [ ]

   11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                     3.83%

   12.      TYPE OF REPORTING PERSON (See Instructions)

                     IN




--------------------                                         -------------------
CUSIP No.  66986W108                   13G/A                 Page 4 of 9 Pages
--------------------                                         -------------------


    1.      NAMES OF REPORTING PERSONS

            Mr. David Kroin

            I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):

    2.      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

            (a)   [ ]

            (b)   [ ]

--------------------------------------------------------------------------------
    3.      SEC USE ONLY


--------------------------------------------------------------------------------

    4.      CITIZENSHIP OR PLACE OF ORGANIZATION

            USA

NUMBER OF SHARES          5.    SOLE VOTING POWER
 BENEFICIALLY
 OWNED BY EACH                                                         0
REPORTING PERSON
      WITH                6.    SHARED VOTING POWER

                                                                    904,908

                          7.    SOLE DISPOSITIVE POWER

                                                                       0

                          8.    SHARED DISPOSITIVE POWER

                                                                    904,908

    9.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                          904,908

   10.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
            (See Instructions)
                                                                             [ ]

   11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                     3.83%

   12.      TYPE OF REPORTING PERSON (See Instructions)

                     IN




--------------------                                         -------------------
CUSIP No.  66986W108                   13G/A                 Page 5 of 9 Pages
--------------------                                         -------------------


     ITEM 1.

                    (a)       Name of Issuer

                              Novamed, Inc.

                    (b)       Address of Issuer's Principal Executive Offices

                              980 North  Michigan Ave, Suite 1620,  Chicago,  IL
                              60611

     ITEM 2.

                    (a)       Name of Person Filing

                                      Great Point Partners, LLC
                                      Dr. Jeffrey R. Jay, M.D.
                                      Mr. David Kroin

                    The  Reporting  Persons  have  entered  into a Joint  Filing
                    Agreement, dated February 17, 2009, a copy of which is filed
                    with this Schedule 13G/A as Exhibit A, pursuant to which the
                    Reporting Persons have agreed to file this statement jointly
                    in accordance with the provisions of Rule 13d-1(k)(1)  under
                    the Act.

                    (b)       Address of Principal  Business Office, or if none,
                              Residence

                              The address of the  principal  business  office of
                              each of the Reporting Persons is

                                  165 Mason Street, 3rd Floor
                                  Greenwich, CT 06830

                    (c)      Citizenship

                    Great Point  Partners,  LLC is a limited  liability  company
                    organized  under  the  laws of the  State of  Delaware.  Dr.
                    Jeffrey R. Jay, M.D. is a citizen of the United States.  Mr.
                    David Kroin. is a citizen of the United States.

                    (d)       Title of Class of Securities

                              Common Stock

                    (e)       CUSIP Number

                              66986W108

     ITEM 3.        IF THIS  STATEMENT IS FILED PURSUANT TO  SS.240.13d-1(b)  OR
                    240.13d.2(b) OR (c), CHECK WHETHER THE PERSON FILING IS A:

                            Not Applicable.

                    (a) [ ]   Broker or dealer  registered  under  Section 15 of
                              the Act (15 U.S.C. 78o)

                    (b) [ ]   Bank as defined in Section  3(a)(6) of the Act (15
                              U.S.C. 78c).

                    (c) [ ]   Insurance  company as defined in Section  3(a)(19)
                              of the Act (15. U.S.C. 78c).

                    (d) [ ]   Investment  Company  registered under Section 8 of
                              the  Investment  Company  Act of 1940  (15  U.S.C.
                              80a-8).

                    (e) [ ]   An   investment   adviser   in   accordance   with
                              ss.240.13d-1(b)(1)(ii)(E).




--------------------                                         -------------------
CUSIP No.  66986W108                   13G/A                 Page 6 of 9 Pages
--------------------                                         -------------------


                    (f) [ ]   An  employee  benefit  plan or  endowment  fund in
                              accordance with ss.240.13d-1(b)(1)(ii)(F).

                    (g) [ ]   A parent  holding  company  or  control  person in
                              accordance with ss.240.13d-1(b)(1)(ii)(G).

                    (h) [ ]   A savings  associations as defined in Section 3(b)
                              of the Federal  Deposit  Insurance  Act (12 U.S.C.
                              1813).

                    (i) [ ]   A church plan that is excluded from the definition
                              of an investment company under Section 3(c)(14) of
                              the  Investment  Company  Act of 1940  (15  U.S.C.
                              80a-3).

                    (j) [ ]   Group,          in         accordance         with
                              ss.240.13d-1(b)(1)(ii)(J).

     ITEM 4.        OWNERSHIP

                    Great Point Partners,  LLC ("Great Point") is the investment
                    manager of  Biomedical  Value  Fund,  L.P.  ("BVF"),  and by
                    virtue of such  status  may be  deemed to be the  beneficial
                    owner of the  570,087  shares of Common  Stock of the Issuer
                    owned by BVF (the "BVF Shares"). Each of Dr. Jeffrey R. Jay,
                    M.D. ("Dr.  Jay"), as senior managing member of Great Point,
                    and Mr.  David  Kroin  ("Mr.  Kroin"),  as special  managing
                    member of Great Point,  has voting and investment power with
                    respect to the BVF Shares, and therefore may be deemed to be
                    the beneficial owner of the BVF Shares.

                    Great Point is the investment manager of Biomedical Offshore
                    Value Fund, Ltd. ("BOVF"),  and by virtue of such status may
                    be deemed to be the  beneficial  owner of the 334,821 shares
                    of  Common  Stock of the  Issuer  owned by BOVF  (the  "BOVF
                    Shares").  Each of Dr.  Jay,  as senior  managing  member of
                    Great Point,  and Mr. Kroin,  as special  managing member of
                    Great Point, has voting and investment power with respect to
                    the BOVF  Shares,  and  therefore  may be  deemed  to be the
                    beneficial owner of the BOVF Shares.

                    Great  Point,  Dr.  Jay and Mr.  Kroin  disclaim  beneficial
                    ownership of the BVF Shares and the BOVF  Shares,  except to
                    the extent of their respective pecuniary interest.


                    Provide the  following  information  regarding the aggregate
                    number  and  percentage  of the class of  securities  of the
                    issuer identified in Item 1.

                    1.        GREAT POINT PARTNERS, LLC

                    (a)       Amount beneficially owned: 904,908

                    (b)       Percent of class: 3.83%

                    (c)       Number of shares as to which the person has:

                              (i)     Sole  power to vote or to direct the vote:
                                      - 0 -

                              (ii)    Shared  power  to  vote or to  direct  the
                                      vote: 904,908

                              (iii)   Sole  power to  dispose  or to direct  the
                                      disposition of: - 0 -.

                              (iv)    Shared  power to  dispose or to direct the
                                      disposition of: 904,908

                    2.        DR. JEFFREY R. JAY, M.D.

                    (a)       Amount beneficially owned: 904,908




--------------------                                         -------------------
CUSIP No.  66986W108                   13G/A                 Page 7 of 9 Pages
--------------------                                         -------------------


                    (b)       Percent of class: 3.83%

                    (c)       Number of shares as to which the person has:

                              (i)     Sole  power to vote or to direct the vote:
                                      0.

                              (ii)    Shared  power  to  vote or to  direct  the
                                      vote: 904,908

                              (iii)   Sole  power to  dispose  or to direct  the
                                      disposition of: 0.

                              (iv)    Shared  power to  dispose or to direct the
                                      disposition of: 904,908

                    3.        MR. DAVID KROIN

                    (a)       Amount beneficially owned: 904,908

                    (b)       Percent of class: 3.83%

                    (c)       Number of shares as to which the person has:

                              (i)     Sole  power to vote or to direct the vote:
                                      0.

                              (ii)    Shared  power  to  vote or to  direct  the
                                      vote: 904,908

                              (iii)   Sole  power to  dispose  or to direct  the
                                      disposition of: 0.

                              (iv)    Shared  power to  dispose or to direct the
                                      disposition of: 904,908

ITEM 5.             OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

                    If this  statement is being filed to report the fact that as
                    of the date hereof each of the Reporting  Persons has ceased
                    to be the beneficial  owner of more than five percent of the
                    class of securities, check the following [X].

ITEM 6.             OWNERSHIP  OF MORE THAN FIVE  PERCENT  ON BEHALF OF  ANOTHER
                    PERSON:

                    See Item 4.

ITEM 7.             IDENTIFICATION  AND  CLASSIFICATION  OF THE SUBSIDIARY WHICH
                    ACQUIRED  THE  SECURITY  BEING  REPORTED  ON BY  THE  PARENT
                    HOLDING COMPANY

                    Not Applicable.

ITEM 8.             IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

                    Not Applicable.

ITEM 9.             NOTICE OF DISSOLUTION OF GROUP

                    Not Applicable.

ITEM 10.            CERTIFICATION

By signing below I certify  that,  to the best of my knowledge  and belief,  the
securities  referred to above were not acquired and are not held for the purpose
of or with the effect of  changing or  influencing  the control of the issuer of
the securities  and were not acquired and are not held in connection  with or as
participant in any transaction having that purpose or effect.




--------------------                                         -------------------
CUSIP No.  66986W108                   13G/A                 Page 8 of 9 Pages
--------------------                                         -------------------


                                    SIGNATURE

After  reasonable  inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

Date:  February 17, 2009


                                            GREAT POINT PARTNERS, LLC

                                            By:  /s/ Dr. Jeffrey R. Jay, M.D.
                                                 -------------------------------
                                                 Dr. Jeffrey R. Jay, M.D.,
                                                   as senior managing member


                                            /s/ Dr. Jeffrey R. Jay, M.D.
                                            ------------------------------------
                                            DR. JEFFREY R. JAY, M.D.



                                            /s/ Mr. David Kroin
                                            ------------------------------------
                                            MR. DAVID KROIN




                                                                       Exhibit A
                                                                       ---------


             AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE 13G/A


The undersigned hereby agree as follows:

         (i)      Each of  them is  individually  eligible  to use the  Schedule
13G/A to which this Exhibit is  attached,  and such  Schedule  13G/A is filed on
behalf of each of them; and

         (ii)     Each of them is  responsible  for the  timely  filing  of such
Schedule 13G/A and any amendments thereto, and for the completeness and accuracy
of the information concerning such person contained therein; but none of them is
responsible for the  completeness or accuracy of the information  concerning the
other  persons  making the filing,  unless  such  person  knows or has reason to
believe that such information is inaccurate.

Date:  February 17, 2009

                                            GREAT POINT PARTNERS, LLC

                                            By:  /s/ Dr. Jeffrey R. Jay, M.D.
                                                 -------------------------------
                                                 Dr. Jeffrey R. Jay, M.D.,
                                                   as senior managing member


                                            /s/ Dr. Jeffrey R. Jay, M.D.
                                            ------------------------------------
                                            DR. JEFFREY R. JAY, M.D.


                                            /s/ Mr. David Kroin
                                            ------------------------------------
                                            MR. DAVID KROIN