RTW Investments, together with Yarrow Biotechnology, announce the appointment of Mark T. Keating as Chief Scientific Officer

Dr. Keating joins from Alnylam Pharmaceuticals, a leading RNAi company, where he served as Vice President and Distinguished Fellow

Yarrow Biotechnology, Inc., an RTW-incubated company developing antisense oligonucleotide (ASO) therapeutics for severe, genetically defined CNS diseases, today announced the appointment of Dr. Mark T. Keating as Chief Scientific Officer. Dr. Keating joins Yarrow from Alnylam Pharmaceuticals, where he served as Vice President and Distinguished Fellow and led multiple programs for extrahepatic delivery of ASO therapeutics, including for CNS disorders.

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“I’m so pleased to be joining the team at Yarrow,” said Dr. Keating. “I firmly believe in the company’s ambition to tackle some of the most devastating CNS diseases through ASO therapy and am excited to play a key role in shaping the journey.”

Dr. Keating has more than 30 years of experience in drug discovery and development across various therapeutic areas. Prior to his role at Alnylam Pharmaceuticals, Dr. Keating served as Vice President and Global Head of Cardiovascular and Metabolic Diseases at Novartis. He played an integral role in the development of Entresto, Novartis’ third largest medicine, and oversaw the discovery and development of more than ten programs that are now in late-stage clinical trials. Earlier in his career, Dr. Keating served as a Howard Hughes Investigator at Harvard Medical School and University of Utah, where his laboratory produced many seminal findings on long QT syndrome (LQTS), discovered LQTS genes such as HERG, and developed the first HERG assay. Dr. Keating is a member of the National Academy of Sciences and the American Academy of Arts and Sciences.

“We are thrilled to have Mark join our team. He is a tremendous scientist and leader with a stellar track record in drug development,” said Peter Fong, PhD, Chief Executive Officer of Yarrow Biotechnology and Head of Company Creation at RTW. “His expertise is tightly aligned with Yarrow’s vision and will help us bring impactful medicines to patients.”

About Yarrow Biotechnology, Inc.

Yarrow is developing ASO therapeutics for severe, genetically defined CNS diseases. Yarrow was founded and incubated by RTW Investments in New York and is rooted in the fund’s longstanding expertise in and commitment to solving genetic diseases and oligotherapeutics.

About RTW Investments

RTW Investments, LP ("RTW") is a global, full life-cycle investment firm that focuses on identifying transformational and disruptive innovations across the biopharmaceutical and medical technologies sectors. As a leading partner of industry and academia, RTW combines deep scientific expertise with a solution-oriented investment approach to support emerging medical therapies and the companies and/or academics developing them. RTW is headquartered in New York with expansion plans in London and Shanghai.

For further information about RTW, please visit www.RTWfunds.com

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