Kairos Pharma (NYSE American: KAPA), a clinical-stage biopharma company developing cancer therapies, announced favorable interim safety results from its ongoing Phase 2 trial of ENV-105 (carotuximab) in patients with metastatic castration-resistant prostate cancer. The first-in-class CD105 antagonist showed no dose-limiting toxicities or unexpected adverse events in the first ten patients, and no Grade 3 or 4 toxicities were observed. ENV-105 was well tolerated when combined with apalutamide, a standard hormone therapy. The 100-patient trial is underway at Cedars-Sinai, City of Hope, and Huntsman Cancer Center, with interim efficacy data expected in September 2025. Kairos plans to engage regulators on a potential Phase 3 study.
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About Kairos Pharma Ltd.
Based in Los Angeles, California, Kairos Pharma is at the forefront of oncology therapeutics, utilizing structural biology to overcome drug resistance and immune suppression in cancer. Its lead candidate, ENV105, is an antibody that targets CD105—a protein identified as a key driver of resistance to various cancer treatments. Elevation of CD105 in response to standard therapy results in resistance and disease relapse. ENV105 aims to reverse drug resistance by targeting CD105 and restore the effectiveness of standard therapies across multiple cancer types. Currently, ENV105 is in a Phase 2 clinical trial for castrate resistant prostate cancer and a Phase 1 trial for lung cancer, addressing significant unmet medical needs. For more information, visit the company’s website at www.KairosPharma.com.
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