Enveric Biosciences, Inc. (NASDAQ: ENVB) (“Enveric” or the “Company”), a biotechnology company dedicated to the development of novel small-molecule therapeutics for the treatment of anxiety, depression, and addiction disorders, today announced that its research involving the synthesis of small molecule derivatives of psychoactive compounds has been featured in two poster presentations at the Canadian Chemistry Conference and Exhibition (CSC 2023) being held in Vancouver June 4-8, 2023.
The first poster titled, “Novel psilocin prodrugs with altered pharmacological properties as candidate therapies for treatment-resistant anxiety disorders,” describes the chemical synthesis of Enveric’s EVM201 Series molecules to identify novel prodrugs of psilocin with altered metabolic profiles and reduced pharmacological exposure aimed at reducing the duration of the psychedelic experience. Beginning with 30 unique molecules, representing nine distinct prodrug classes, 15 candidates were selected that released the highest levels of psilocin in vitro. Pharmacokinetic analysis confirmed that the efficient release of psilocin in vitro correlated with the amount of psilocin detected in blood plasma. Two molecules that produced plasma psilocin concentrations comparable or superior to psilocybin were evaluated for long-term anxiolytic benefit in chronically stressed mice using the marble-burying psychiatric model.
The second poster titled, “Design, synthesis and pharmacological evaluation of novel MDMA derivatives as potential therapies for the treatment of psychiatric conditions,” describes the design and chemical synthesis of a library of 30 novel MDMA (Ecstasy) derivatives. The compounds were tested for their ability to bind serotonin receptors and transporters. The results show how modifications to the chemical structure of MDMA can lead to substantial alteration in binding to different serotonin receptors and transporters, which could alter pharmacological properties.
“The two posters presented at CSC 2023 showcase the pioneering work of our researchers and collaborators, who are using cutting-edge techniques to produce novel therapeutic candidates that harness key properties of known psychoactive compounds but are designed to display safer pharmacologic profiles more applicable in the mental health setting,” said Joseph Tucker, Ph.D., Director and CEO of Enveric. “We are proud to see the work of our research teams presented at this prestigious scientific conference, and we look forward to their continued contributions to this important field, which we feel has the potential to generate new and improved treatments for people living with mental health conditions.”
Details of the poster presentations are as follows:
Title: Novel psilocin prodrugs with altered pharmacological properties as candidate therapies for treatment-resistant anxiety disorders
Presenter: Sheetal A. Raithatha, Enveric Biosciences
Authors: Sheetal A. Raithatha, Jill M. Hagel, Kaveh Matinkhoo, Lisa Yu, David Press, Govinda Sharma, Dhananjaya D., Sarah G. Cook, Glynnis Jensen, Jessica Lee, Charlie Cai, Jonathan Gallant, Stanley Opare, Xue Chen, Jing Li, Limei Chang, Francesca Maule, Joseph E. Tucker, Peter J. Facchini
Title: Design, synthesis and pharmacological evaluation of novel MDMA derivatives as potential therapies for the treatment of psychiatric conditions
Presenter: Kaveh Matinkhoo, Enveric Biosciences
Authors: Kaveh Matinkhoo, Jill M. Hagel, Sheetal A. Raithatha, David Press, Glynnis Jensen, Jessica Lee, Charlie Cai, Lisa Yu, Govinda Sharma, Dhananjaya D., Sarah G. Cook, Jonathan Gallant, Stanley Opare, Xue Chen, Jing Li, Limei Chang, Francesca Maule, Joseph E. Tucker, Peter J. Facchini
About Enveric Biosciences
Enveric Biosciences (NASDAQ: ENVB) is a biotechnology company dedicated to the development of novel small-molecule therapeutics for the treatment of anxiety, depression, and addiction disorders. Leveraging its unique discovery and development platform, The Psybrary™, Enveric has created a robust Intellectual Property portfolio of New Chemical Entities for specific mental health indications. Enveric’s lead program, the EVM201 Series, comprises next generation synthetic prodrugs of the active metabolite, psilocin. Enveric is developing the first product from the EVM201 Series – EB-373 – for the treatment of anxiety disorders. Enveric is also advancing its second program, the EVM301 Series, to offer a first-in-class, new approach to the treatment of difficult-to-address mental health disorders, mediated by the promotion of neuroplasticity without also inducing hallucinations in the patient. Enveric is headquartered in Naples, FL with offices in Cambridge, MA and Calgary, AB Canada. For more information, please visit www.enveric.com.
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