PURCHASE, N.Y., March 17, 2026 (GLOBE NEWSWIRE) -- Cognition Therapeutics, Inc., (the “Company” or “Cognition”) (NASDAQ: CGTX), a clinical-stage company developing drugs that treat neurodegenerative disorders, presented an analysis from the Phase 2 COG1201 SHIMMER study (NCT05225415) of zervimesine (CT1812) in dementia with Lewy bodies (DLB) at the AD/PD™ 2026 Alzheimer's & Parkinson's Diseases Conference. The conference is being conducted March 17-21, 2026 in Copenhagen, Denmark. The analysis focuses on Zervimesine’s treatment effects on the behavioral and psychiatric symptoms most commonly associated with DLB.

“In the Phase 2 ‘SHIMMER’ study, we saw a treatment effect across neuropsychiatric, cognitive, motor, and global function domains with zervimesine treatment compared to placebo,” explained Anthony Caggiano, MD, PhD, Cognition’s CMO. “This effect was particularly robust against DLB’s behavioral and psychiatric symptoms, which have been identified as important to patients and care partners. We’re presenting a breakdown of zervimesine’s effect relative to placebo on the components of the neuropsychiatric index (NPI), which was employed in the Phase 2 study.”

Zervimesine treatment resulted in an 86% slowing of decline on NPI-12 vs placebo in that Phase 2 study. This slowing of decline reflects zervimesine’s unique disease-modifying mechanism of action. Acute treatments for psychosis may improve one symptom but will not delay progression of the disease. Based on our clinical data, we believe zervimesine has the potential to slow DLB progression and reduce the progression of its associated neuropsychiatric symptoms.

Its unique mechanism should also allow zervimesine to be used in DLB patients who cannot tolerate traditional antipsychotics and benzodiazepines. Some medications, such as haloperidol, are contraindicated in patients with DLB, who may exhibit severe parkinsonism, sedation, and immobility in response. Unlike traditional antipsychotics, zervimesine demonstrated a directionally favorable impact on cognitive fluctuations, memory, movement symptoms, and activities of daily living.

Poster Details:

• Grundman M, Galvin J, Iaci J, et al. Zervimesine Slows Progression of Symptoms in Mild-to-moderate Dementia with Lewy Bodies
• Grundman M, Iaci J, Hendrix S, et al. A Global Statistical Test Approach to Clinical Trials with Zervimesine for Dementia with Lewy Bodies
  
  

Posters presented at AD/PD will be available on the Cognition Therapeutics website in accordance with the conference’s embargo policy.

Based on a recent Type C meeting with the U.S. Food and Drug Administration (FDA) and the strength of Phase 2 results, the Company recently announced plans to develop zervimesine for the treatment of DLB psychosis. These symptoms include the hallucinations, delusions, agitation, and anxiety that are reported to be extremely unsettling to patients and typically worsen as DLB progresses.

“The data we are presenting at AD/PD demonstrate that zervimesine had a robust impact on the neuropsychiatric symptoms, which are a hallmark of DLB,” concluded Dr. Caggiano. “While antipsychotic medications exist, many can't be used in DLB patients due to a severe and sometimes life-threating sensitivity to these drugs. Zervimesine’s unique mechanism of action may represent a tolerable solution for patients with these burdensome symptoms. We believe that pursuing development of zervimesine for the treatment of DLB’s neuropsychiatric symptoms will meet a critical need for DLB patients.”

Psychosis in DLB
Patients with dementia commonly experience behavioral and psychological symptoms such as aggression, agitation, and depression. As many as 75% of patients with DLB will experience psychosis, which presents a considerable burden to patients and caregivers. In addition to impeding daily activities, neuropsychiatric symptoms lead to higher healthcare costs and earlier institutionalization. While antipsychotics are available for other conditions, none are approved for use in DLB patients. In fact, many traditional antipsychotics, such as haloperidol, are contraindicated in patients with DLB, who may exhibit severe parkinsonism, sedation, and immobility in response to these medications.

About Cognition Therapeutics:
Cognition Therapeutics, Inc. is a clinical-stage biopharmaceutical company dedicated to helping millions of families seeking effective treatments for devastating neurodegenerative diseases through the development of novel, accessible therapies. The company has led pioneering research into the underlying mechanisms of degenerative nerve disorders. Our scientific approach builds on well-established biological pathways and translates across indications in which toxic oligomers drive disease progression, offering potential in dementia with Lewy bodies (DLB), Alzheimer’s disease, geographic atrophy, Parkinson’s, among others. The company’s lead candidate, zervimesine (CT1812), is an investigational once-daily oral therapy that has demonstrated promise in Phase 2 clinical trials in DLB and mild-to-moderate Alzheimer’s disease. Backed by nearly $200 million in National Institutes of Health and related foundation grants, Cognition Therapeutics continues to advance clinical research in its efforts to bring forth solutions that meet patients where they are and reduce caregiver burden. Learn more at cogrx.com.

About Zervimesine (CT1812)
Zervimesine (CT1812) is currently being studied in the Phase 2 START Study (NCT05531656) in patients with MCI and early Alzheimer’s disease. Phase 2 clinical studies have been completed in dementia with Lewy bodies (DLB), mild-to-moderate Alzheimer’s disease, and geographic atrophy secondary to dry AMD. Based in part on the strong efficacy signals observed in the Phase 2 SHIMMER study in DLB (NCT05225415), the company plans to advance zervimesine into a late-stage clinical trial for people with DLB psychosis. Zervimesine has been generally well tolerated in clinical studies to date.

The USAN Council has adopted zervimesine as the United States Adopted Name (USAN) for CT1812.

Forward-Looking Statements 
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